中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2014年
12期
1458-1459
,共2页
翟勇亚%施晓鹂%张伟%张斌
翟勇亞%施曉鸝%張偉%張斌
적용아%시효리%장위%장빈
年龄因素%依托咪酯%清醒镇静
年齡因素%依託咪酯%清醒鎮靜
년령인소%의탁미지%청성진정
Aged factors%Etomidate%Conscious sedation
目的 评价年龄因素对依托咪酯镇静效力的影响.方法 拟在全身麻醉下行择期手术患者150例,ASA分级Ⅰ或Ⅱ级,按年龄分为3组(n=50),青年组(Y组):18～ 39岁;中年组(M组):40～64岁;老年组(0组):65～75岁.每组采用随机数字表法分为5个亚组(n=.10):分别静脉注射依托咪酯0.07、0.09、0.11、0.13或0.17 mg/kg.注射后5 min内观察意识是否消失(睫毛反射消失).结果 Y组、M组和O组依托咪酯使患者意识消失的半数有效剂量(ED50)分别为0.13、0.11和0.09mg/kg.与Y组比较,O组ED50降低(P＜0.05),M组ED50差异无统计学意义(P＞0.05).结论 年龄因素可影响依托咪酯镇静效力,依托咪酯对老年患者的镇静效力增强.
目的 評價年齡因素對依託咪酯鎮靜效力的影響.方法 擬在全身痳醉下行擇期手術患者150例,ASA分級Ⅰ或Ⅱ級,按年齡分為3組(n=50),青年組(Y組):18～ 39歲;中年組(M組):40～64歲;老年組(0組):65～75歲.每組採用隨機數字錶法分為5箇亞組(n=.10):分彆靜脈註射依託咪酯0.07、0.09、0.11、0.13或0.17 mg/kg.註射後5 min內觀察意識是否消失(睫毛反射消失).結果 Y組、M組和O組依託咪酯使患者意識消失的半數有效劑量(ED50)分彆為0.13、0.11和0.09mg/kg.與Y組比較,O組ED50降低(P＜0.05),M組ED50差異無統計學意義(P＞0.05).結論 年齡因素可影響依託咪酯鎮靜效力,依託咪酯對老年患者的鎮靜效力增彊.
목적 평개년령인소대의탁미지진정효력적영향.방법 의재전신마취하행택기수술환자150례,ASA분급Ⅰ혹Ⅱ급,안년령분위3조(n=50),청년조(Y조):18～ 39세;중년조(M조):40～64세;노년조(0조):65～75세.매조채용수궤수자표법분위5개아조(n=.10):분별정맥주사의탁미지0.07、0.09、0.11、0.13혹0.17 mg/kg.주사후5 min내관찰의식시부소실(첩모반사소실).결과 Y조、M조화O조의탁미지사환자의식소실적반수유효제량(ED50)분별위0.13、0.11화0.09mg/kg.여Y조비교,O조ED50강저(P＜0.05),M조ED50차이무통계학의의(P＞0.05).결론 년령인소가영향의탁미지진정효력,의탁미지대노년환자적진정효력증강.
Objective To evaluate the influence of age factors on etomidate sedative potency.Methods One hundred and fifty (ASA physical status Ⅰ or Ⅱ) patients of both sexes,scheduled for elective operation under general anesthesia,were divided into 3 groups according to age (n =50 each):group Y 18-44 yr,group M 40-64 yr and group O 65-75 yr.Each group was randomly divided into 5 subgroups receiving in'venous etomidate 0.07,0.09,0.11,0.13 and 0.17 mg/kg,respectively.Loss of consciousness was evaluated depending on loss of eyelash reflex within 5 min after intravenous administration.Results ED50 of etomidate inducing loss of consciousness was 0.13,0.11 and 0.09 mg/kg in group Y,M and O,respectively.Compared with that in group Y,ED50 was significantly decreased in group O,however,and showed no significant change in group M.Conclusion Age factors can affect sedative potency of etomidate,which appears greater in the elderly patients.
