CAJ | 학술논문

目的探讨肠道病毒(EV)71型(EV71)所致疾病的流行特征.方法对江苏省及北京市7个研究现场10 158名6～35月龄儿童进行为期1年的队列随访,系统调查EV71所致疾病及其流行病学特征.结果 EV71感染所致疾病发病密度为15.17/千人年,其中手足口病、疱疹性咽峡炎、呼吸系统疾病、消化系统疾病和其他疾病分别占82.00％、2.67％、13.33％、1.33％和0.67％.病例以12～ 23月龄婴儿为主(58.67％),不同月龄组发病密度之间的差异有统计学意义(f=7.789,P=0.020).发病时间主要集中在4-6月;重症病例9例(男性7例,女性2例),占病例总数的6.00％,均为手足口病病例;3个年龄段(6～11、12～23、24～35月龄)重症病例分别为1、7、1例.手足口病、非手足口病病例的病程M值分别为9d和6d,差异有统计学意义(Z=-4.000,P＜0.001),排毒周期的M值分别为9d和11d,差异无统计学意义.结论 EV71感染所致疾病以手足口病为主,主要影响婴幼儿,且具有一定的季节性.
목적 탐토장도병독(EV)71형(EV71)소치질병적류행특정.방법 대강소성급북경시7개연구현장10 158명6～35월령인동진행위기1년적대렬수방,계통조사EV71소치질병급기류행병학특정.결과 EV71감염소치질병발병밀도위15.17/천인년,기중수족구병、포진성인협염、호흡계통질병、소화계통질병화기타질병분별점82.00％、2.67％、13.33％、1.33％화0.67％.병례이12～ 23월령영인위주(58.67％),불동월령조발병밀도지간적차이유통계학의의(f=7.789,P=0.020).발병시간주요집중재4-6월;중증병례9례(남성7례,녀성2례),점병례총수적6.00％,균위수족구병병례;3개년령단(6～11、12～23、24～35월령)중증병례분별위1、7、1례.수족구병、비수족구병병례적병정M치분별위9d화6d,차이유통계학의의(Z=-4.000,P＜0.001),배독주기적M치분별위9d화11d,차이무통계학의의.결론 EV71감염소치질병이수족구병위주,주요영향영유인,차구유일정적계절성.
Objective The objective of this study was to investigate the epidemiological characteristics of disease caused by enterovirus type 71.Methods A total of 10 158 children aged between 6 and 35 months,were recruited from 7 sites where EV71 inactivated vaccine phase 3 clinical trial was carded out.All the subjects were followed up to one year to investigate the epidemiological characteristics of the disease caused by EV71.Results The accumulate incidence density of disease caused by EV71 was 15.17/1 000 person-year.Of all the cases,hand,foot and mouth disease (HFMD),herpangina,respiratory system diseases,digestive system diseases and other diseases accounted for 82.00％,2.67％,13.33％,1.33％ and 0.67％,respectively.The difference of the incidence density between boys and girls showed no statistical significance.Majority of the patients were between 12 and 23 months of age,which accounted for 58.67％ of the total patients.The differences of incidence density between different months of age were statistically significant (x2=7.789,P=0.020).The peak incidence density of disease caused by EV71 occurred from April to June.Nine cases showed severe symptoms or signs that accounted for 6.00％ of all the cases.All severe cases were identified as HFMD,of which 7 were boys and 2 were girls.The number of severe cases in different months of age appeared to be 1,7,and 1,all occurred between April and June.The median courses of HFMD cases and non-HFMD cases were 9 and 6 days,with difference statistically significant (Z=-4.000,P＜0.001).Median of excretion cycle for HFMD and non-HFMD cases were 9 and 11 days respectively.But with no statistically significant difference between the two.Conclusion Majority of the disease that caused by EV71 appeared as HFMD.Most of them were younger children and with seasonal variation.