中华航海医学与高气压医学杂志
中華航海醫學與高氣壓醫學雜誌
중화항해의학여고기압의학잡지
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
2014年
6期
369-371
,共3页
乔翠霞%赵刚%万金娥%张立泽%刘鹏林
喬翠霞%趙剛%萬金娥%張立澤%劉鵬林
교취하%조강%만금아%장립택%류붕림
高压氧%溃疡性结肠炎%T淋巴细胞亚群
高壓氧%潰瘍性結腸炎%T淋巴細胞亞群
고압양%궤양성결장염%T림파세포아군
Hyperbaric oxygen%Ulcerative colitis%T-lymphocyte subgroup
目的 观察高压氧(HBO)综合治疗溃疡性结肠炎的临床疗效及抗复发情况,探讨HBO抗溃疡性结肠炎复发的可能作用机制.方法 将70例溃疡性结肠炎患者按治疗方法分为2组:治疗组36例和对照组34例,治疗组HBO联合柳氮磺胺吡啶(SASP)治疗,对照组单用SASP治疗,2组均治疗45 d.结果 治疗组总有效率为94.44%,高于对照组的67.64%,复发率为11.76%,低于对照组的39.13%,差异有统计学意义(P<0.05,P<0.01).结论 HBO联合SASP治疗溃疡性结肠炎疗效好,复发率低,其可能机制为:通过抑制T淋巴细胞亚群的过度增殖,改善T淋巴细胞亚群的比例失调,调衡细胞免疫状态,达到抑制溃疡性结肠炎复发的目的.
目的 觀察高壓氧(HBO)綜閤治療潰瘍性結腸炎的臨床療效及抗複髮情況,探討HBO抗潰瘍性結腸炎複髮的可能作用機製.方法 將70例潰瘍性結腸炎患者按治療方法分為2組:治療組36例和對照組34例,治療組HBO聯閤柳氮磺胺吡啶(SASP)治療,對照組單用SASP治療,2組均治療45 d.結果 治療組總有效率為94.44%,高于對照組的67.64%,複髮率為11.76%,低于對照組的39.13%,差異有統計學意義(P<0.05,P<0.01).結論 HBO聯閤SASP治療潰瘍性結腸炎療效好,複髮率低,其可能機製為:通過抑製T淋巴細胞亞群的過度增殖,改善T淋巴細胞亞群的比例失調,調衡細胞免疫狀態,達到抑製潰瘍性結腸炎複髮的目的.
목적 관찰고압양(HBO)종합치료궤양성결장염적림상료효급항복발정황,탐토HBO항궤양성결장염복발적가능작용궤제.방법 장70례궤양성결장염환자안치료방법분위2조:치료조36례화대조조34례,치료조HBO연합류담광알필정(SASP)치료,대조조단용SASP치료,2조균치료45 d.결과 치료조총유효솔위94.44%,고우대조조적67.64%,복발솔위11.76%,저우대조조적39.13%,차이유통계학의의(P<0.05,P<0.01).결론 HBO연합SASP치료궤양성결장염료효호,복발솔저,기가능궤제위:통과억제T림파세포아군적과도증식,개선T림파세포아군적비례실조,조형세포면역상태,체도억제궤양성결장염복발적목적.
Objective To observe the clinical effects of hyperbaric oxygen (HBO) comprehensive treatment on ulcerative colitis and resistance to recurrence and to explore possible mechanism involved in the recurrence of the disease.Methods Seventy cases of ulcerative colitis were randomly divided into 2 groups:the treatment group (n =36) and the control group (n =34).The treatment group was treated with HBO combined with sulfasalazine (SASP) for 45 days,while the control group was only treated with SASP for the same length of time.Results The therapeutic effects on the treatment group were superior to those of the control group,and the recurrence rate was lower than that of the control group,with statistical difference (P < 0.05,P <0.01).Conclusions HBO combined with SASP produced good effects on ulcerative colitis,with low recurrence rate.The possible mechanism might be associated with the inhibition of excessive T-lymphocyte subgroup proliferation,improvement of T lymphocyte subgroup imbalance and adjustment of cell immune status,thus suppressing the recurrence of ulcerative colitis.