CAJ | 학술논문

钙调素(Regucalcin)是一种多功能蛋白,参与维持细胞内钙稳态,调节多种酶活性,抑制氧化应激以及调控细胞增殖凋亡.钙调素在肝脏中含量较高.在多种肝脏疾病中,钙调素基因及其蛋白表达水平发生改变.这些改变在肝脏疾病的发生发展中起到重要作用.本文就钙调素在肝脏疾病中的作用进行综述.
개조소(Regucalcin)시일충다공능단백,삼여유지세포내개은태,조절다충매활성,억제양화응격이급조공세포증식조망.개조소재간장중함량교고.재다충간장질병중,개조소기인급기단백표체수평발생개변.저사개변재간장질병적발생발전중기도중요작용.본문취개조소재간장질병중적작용진행종술.
Regucalcin is considered as a multifunctional protein involved in maintaining cellular calcium homeostasis,altering activities of many enzymes,suppressing oxidant stress and regulating cellular proliferation and apoptosis.The level of regucalcin is much higher in liver than in any other organs; and its gene expression together with protein content are altered in many liver diseases.These changes may play a significant role in both generation and development of numerous hepatopathy.This review will focus on recent advances made to understanding the function of regucalcin in multiple liver diseases.