CAJ | 학술논문

目的通过对胰腺癌组织及对应的癌旁无瘤组织中转录中介因子1β (TIF1β)的表达进行分析,探讨其表达与胰腺癌患者临床病理因素的关系.方法利用组织芯片技术结合免疫组化法检测91例胰腺癌组织及对应癌旁无瘤组织中TIF1β蛋白的表达.结果 TIF1β蛋白在胰腺癌组织及对应癌旁无瘤组织中均有不同程度的表达,其定位于胞核,胰腺癌组织中TIF1β阳性表达率显著高于癌旁组织(P ＜0.05);TIF1β的表达与临床病理分期、淋巴转移及TNM分级相关(P＜0.05).结论 TIF1β在胰腺癌中高表达,并且与胰腺癌的临床病理分期、淋巴转移及TNM分级有关.TIF1β可能在胰腺癌的发生发展过程中起重要促进作用.
목적 통과대이선암조직급대응적암방무류조직중전록중개인자1β (TIF1β)적표체진행분석,탐토기표체여이선암환자림상병리인소적관계.방법 이용조직심편기술결합면역조화법검측91례이선암조직급대응암방무류조직중TIF1β단백적표체.결과 TIF1β단백재이선암조직급대응암방무류조직중균유불동정도적표체,기정위우포핵,이선암조직중TIF1β양성표체솔현저고우암방조직(P ＜0.05);TIF1β적표체여림상병리분기、림파전이급TNM분급상관(P＜0.05).결론 TIF1β재이선암중고표체,병차여이선암적림상병리분기、림파전이급TNM분급유관.TIF1β가능재이선암적발생발전과정중기중요촉진작용.
Objective To investigate transcription intermediary factor 1β (TIF1β) expression in paracancerous pancreatic tissue and pancreatic tumor tissue by using tissue microarray.The relationship between TIF1β expression and clinicopathological factors in patients with pancreatic cancer was discussed.Method Tissuc microarray and immunohistochemical assay were utilized to detect expression of TIF1β protein in pancreatic cancer tissues and the corresponding non-tumor tissues from 91 cases.Results TIF1β protein were present in pancreatic cancer tissues as well as corresponding non-tumor tissues with varying degrees of expression,and was located in the nucleus.TIF1β expression in pancreatic cancer tissue was significantly higher than that of adjacent tissues (P ＜ 0.05).And it was noted that there was close correlations between TIF1β expression and clinical pathological staging,lymph node metastasis and TNM grading (P ＜ 0.05).Conclusions TIF1β is highly expressed in pancreatic cancer,clinically correlated with pathological staging,lymph node metastasis and TNM grading.TIF1β may play an important role in development of pancreatic cancer.