CAJ | 학술논문

目的探讨乳腺浸润性导管癌与导管内癌的超声造影表现与癌基因C-erbB-2、Ki-67表达的相关性.方法回顾性分析29例乳腺浸润性导管癌和12例乳腺导管内癌患者的超声造影特征及定量分析,所有病例均经手术或穿刺病理确诊,术后对肿瘤标本用免疫组化方法测定C-erbB-2、Ki 67表达情况,并分析其与超声造影表现之间的关系.结果 29例乳腺浸润性导管癌肿块Ki-67表达阳性率68.97％(20/29),C-erbB-2表达阳性率48.2％ (14/29);12例导管内癌肿块Ki-67表达阳性率16.67％(2/12),C-erbB-2表达阳性率42.6％(5/12).乳腺浸润性导管癌与导管内癌肿块均以高增强为主,与C-erbB-2表达相关性不明显.乳腺浸润性导管癌Ki-67阳性表达率明显高于导管内癌,超声造影表现出现灌注缺损与Ki-67表达阳性有相关性.结论乳腺浸润性导管癌与导管内癌在超声造影肿瘤微血管灌注特点上与分子生物学指标Ki-67蛋白之间存在一定的相关性.
목적 탐토유선침윤성도관암여도관내암적초성조영표현여암기인C-erbB-2、Ki-67표체적상관성.방법 회고성분석29례유선침윤성도관암화12례유선도관내암환자적초성조영특정급정량분석,소유병례균경수술혹천자병리학진,술후대종류표본용면역조화방법측정C-erbB-2、Ki 67표체정황,병분석기여초성조영표현지간적관계.결과 29례유선침윤성도관암종괴Ki-67표체양성솔68.97％(20/29),C-erbB-2표체양성솔48.2％ (14/29);12례도관내암종괴Ki-67표체양성솔16.67％(2/12),C-erbB-2표체양성솔42.6％(5/12).유선침윤성도관암여도관내암종괴균이고증강위주,여C-erbB-2표체상관성불명현.유선침윤성도관암Ki-67양성표체솔명현고우도관내암,초성조영표현출현관주결손여Ki-67표체양성유상관성.결론 유선침윤성도관암여도관내암재초성조영종류미혈관관주특점상여분자생물학지표Ki-67단백지간존재일정적상관성.
Objective To evaluate the relation of appearance of contrast-enhanced ultrasonography (CEUS) to Ki 67 and C-erbB-2 in breast invasive ductal carcinoma and ductal carcinoma in situ.Methods The appearance of CEUS in 29 patients with breast invasive ductal carcinoma and 12 patients with ductal carcinoma in situ,which was diagnosed by surgery or biopsy,was analysed retrospectively.The Ki-67 and CerbB-2 were measured by immunohistochemical test.The relation of the above two factors to appearance of contrast ultrasonography was analysed.Results The positive rate of Ki-67 was 68.97％ (20/29) in patients with breast invasive ductal carcinoma and 16.67％ (2/12) in patients with ductal carcinoma in situ.The positive rate of C-erbB-2 was 48.2％ (14/29) in patients with breast invasive ductal carcinoma and 42.6％ (5/12) in patients with ductal carcinoma in situ.The masses had a common appearance of high enhance in patients with breast invasive ductal carcinoma and ductal carcinoma in situ,which was not correlated to C-erbB-2.The Ki-67 was significantly higher in patients with ductal carcinoma in situ than that in patients with breast invasive ductal carcinoma,the appearance of CEUS was correlated to Ki 67.Conclusions The features of micro-vessels by CEUS were correlated to Ki-67 in patients with breast invasive ductal carcinoma and ductal carcinoma in situ.