中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
12期
1334-1336
,共3页
牛雅%黄秋芳%朱伟娜%杨彩珍
牛雅%黃鞦芳%硃偉娜%楊綵珍
우아%황추방%주위나%양채진
磷酸肌酸%儿童%轮状病毒肠炎%心肌损伤
燐痠肌痠%兒童%輪狀病毒腸炎%心肌損傷
린산기산%인동%륜상병독장염%심기손상
Creatine phosphate%Infantile%Rotaviral enteritis%Myocardial damage
目的 观察磷酸肌酸治疗小儿轮状病毒肠炎合并心肌损伤的临床效果.方法 120例轮状病毒肠炎合并心肌损伤患儿按照随机数字表分为对照组和观察组各60例,两组患儿均给予抗病毒、补液、营养支持、纠正酸碱平衡紊乱和电解质紊乱等常规治疗,对照组在常规治疗基础上加用1,6-二磷酸果糖160 mg/(kg·d)静脉滴注,1次/d;观察组在常规治疗基础上联合应用磷酸肌酸1.0g加入5％葡萄糖注射液150 ml中静脉滴注,1次/d.疗程均为7d,比较两组患儿治疗前后心肌酶的变化、临床效果及不良反应发生情况.结果 (1)观察组总有效率为95.0％ (57/60),对照组为80.0％ (48/60),两组比较差异有统计学意义(x2 =6.268,P＜0.05).(2)治疗前两组心肌酶差异无统计学意义(P均＞0.05),观察组治疗后乳酸脱氢酶为(163.8±18.5) U/L,肌酸激酶为(152.8±26.4) U/L,肌酸激酶同工酶为(19.4±7.8) U/L,天冬氨酸氨基转移酶为(24.4±6.8) U/L;对照组分别为(193.4±22.8)、(168.6±32.6)、(27.4±9.2)、(35.4±9.8) U/L,两组间比较差异有统计学意义(t值分别为3.484、3.228、4.278和4.729,P均＜0.05).(3)两组患者治疗期间均未发生明显不良反应.结论 磷酸肌酸治疗小儿轮状病毒肠炎合并心肌损伤临床效果显著,安全性好,值得在临床推广应用.
目的 觀察燐痠肌痠治療小兒輪狀病毒腸炎閤併心肌損傷的臨床效果.方法 120例輪狀病毒腸炎閤併心肌損傷患兒按照隨機數字錶分為對照組和觀察組各60例,兩組患兒均給予抗病毒、補液、營養支持、糾正痠堿平衡紊亂和電解質紊亂等常規治療,對照組在常規治療基礎上加用1,6-二燐痠果糖160 mg/(kg·d)靜脈滴註,1次/d;觀察組在常規治療基礎上聯閤應用燐痠肌痠1.0g加入5％葡萄糖註射液150 ml中靜脈滴註,1次/d.療程均為7d,比較兩組患兒治療前後心肌酶的變化、臨床效果及不良反應髮生情況.結果 (1)觀察組總有效率為95.0％ (57/60),對照組為80.0％ (48/60),兩組比較差異有統計學意義(x2 =6.268,P＜0.05).(2)治療前兩組心肌酶差異無統計學意義(P均＞0.05),觀察組治療後乳痠脫氫酶為(163.8±18.5) U/L,肌痠激酶為(152.8±26.4) U/L,肌痠激酶同工酶為(19.4±7.8) U/L,天鼕氨痠氨基轉移酶為(24.4±6.8) U/L;對照組分彆為(193.4±22.8)、(168.6±32.6)、(27.4±9.2)、(35.4±9.8) U/L,兩組間比較差異有統計學意義(t值分彆為3.484、3.228、4.278和4.729,P均＜0.05).(3)兩組患者治療期間均未髮生明顯不良反應.結論 燐痠肌痠治療小兒輪狀病毒腸炎閤併心肌損傷臨床效果顯著,安全性好,值得在臨床推廣應用.
목적 관찰린산기산치료소인륜상병독장염합병심기손상적림상효과.방법 120례륜상병독장염합병심기손상환인안조수궤수자표분위대조조화관찰조각60례,량조환인균급여항병독、보액、영양지지、규정산감평형문란화전해질문란등상규치료,대조조재상규치료기출상가용1,6-이린산과당160 mg/(kg·d)정맥적주,1차/d;관찰조재상규치료기출상연합응용린산기산1.0g가입5％포도당주사액150 ml중정맥적주,1차/d.료정균위7d,비교량조환인치료전후심기매적변화、림상효과급불량반응발생정황.결과 (1)관찰조총유효솔위95.0％ (57/60),대조조위80.0％ (48/60),량조비교차이유통계학의의(x2 =6.268,P＜0.05).(2)치료전량조심기매차이무통계학의의(P균＞0.05),관찰조치료후유산탈경매위(163.8±18.5) U/L,기산격매위(152.8±26.4) U/L,기산격매동공매위(19.4±7.8) U/L,천동안산안기전이매위(24.4±6.8) U/L;대조조분별위(193.4±22.8)、(168.6±32.6)、(27.4±9.2)、(35.4±9.8) U/L,량조간비교차이유통계학의의(t치분별위3.484、3.228、4.278화4.729,P균＜0.05).(3)량조환자치료기간균미발생명현불량반응.결론 린산기산치료소인륜상병독장염합병심기손상림상효과현저,안전성호,치득재림상추엄응용.
Objective To explore the clinical effect of creatine phosphate on infantile with rotaviral enteritis and myocardial damage.Methods One hundred and twenty children with rotaviral enteritis and myocardial damage were randomly divided into the control group (n =60) and observation group (n =60).Two groups were given antiviral,rehydration,nutritional support,redressing acid-base imbalance and electrolyte disorders and other conventional treatment.The patients of the control group were given 160 mg/(kg · d) 1,6Fructose Diphosphate(1 times/d) on the basis of routine treatment,while those in the observation group were given 1.0 g creatine phosphate + 150 ml 5％ glucose injection(1 times/d) on the basis of routine treatment,both courses of two groups were 7 days.The levels of myocardial enzymes were measured and the clinical effect and adverse reactions were recorded.Results The total effective rate in observation group was 95.0％ (57/60),obviously higher than that of control group (80.0％ (48/60)) and the differences were statistically significant (x2 =6.268,P ＜ 0.05).There were no statistical significant difference in terms of myocardial enzyme between the two groups before treatment(P ＞0.05).The level of lactate dehydmgenase(LDH),creatine kinase (CK),creatine kinase isoenzyme (CK-MB) and aspartate aminotransferase (AST) of observation group were (163.8 ±18.5) U/L,(152.8±26.4) U/L,(19.4±7.8) U/Land (24.4 ±6.8) U/Lafter treatment,and (193.4 ± 22.8) U/L,(168.6 ± 32.6) U/L,(27.4 ± 9.2) U/L and (35.4 ± 9.8) U/L of control group,and the differences between the two groups were significant (t =3.484,3.228,4.278 and 4.729; P ＜ 0.05).There was no obvious adverse reaction during the treatment course.Conclusion The clinical effect of creatine phosphate on infantile with rotaviral enteritis and myocardial damage is remarkable and safe,and it is worth of clinical application.
