中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
12期
1287-1290
,共4页
戚晓渊%孙泽林%戚素银%王颖%张彦%孙泽辉
慼曉淵%孫澤林%慼素銀%王穎%張彥%孫澤輝
척효연%손택림%척소은%왕영%장언%손택휘
2型糖尿病%糖尿病视网膜病变%瘦素%脂联素
2型糖尿病%糖尿病視網膜病變%瘦素%脂聯素
2형당뇨병%당뇨병시망막병변%수소%지련소
Type 2 diabetes mellitus%Diabetic retinopathy%Leptin%Adiponectin
目的 探讨糖尿病视网膜病变患者血清瘦素和脂联素水平的变化及其临床意义.方法 收集2012年11月至2013年11月在河北联合大学附属医院内分泌科就诊的2型糖尿病患者121例,其中糖尿病无视网膜病变41例,非增殖性视网膜病变40例,增殖性视网膜病变40例,另设健康体检者40名为对照组.采用ELISA法测定各组研究对象血清瘦素和脂联素.结果 实验组血清瘦素为(15.25±4.70) μg/L,较对照组[(6.15±1.70) g/L]增高,脂联素为(7.39±1.92) mg/L,较对照组[(11.10±1.46) mg/L]降低,差异均有统计学意义(t值分别为-11.696、11.216,P均＜0.01).无视网膜病变组、非增殖性视网膜病变组和增殖性视网膜病变组血清瘦素分别为(10.91±1.21)、(15.22±3.75)、(20.50±3.70)μg/L;脂联素分别为(9.61±1.35)、(7.11±1.18)、(5.34±1.36) mg/L,各组间比较差异均有统计学意义(F值分别为149.542、291.550,P均＜0.05).血清瘦素水平与血清脂联素水平呈负相关(r=-0.662,P.＜0.01).结论 血清瘦素和脂联素水平变化与糖尿病视网膜病变病变程度有关,二者可能成为糖尿病视网膜病变预测和疗效评估的重要指标.
目的 探討糖尿病視網膜病變患者血清瘦素和脂聯素水平的變化及其臨床意義.方法 收集2012年11月至2013年11月在河北聯閤大學附屬醫院內分泌科就診的2型糖尿病患者121例,其中糖尿病無視網膜病變41例,非增殖性視網膜病變40例,增殖性視網膜病變40例,另設健康體檢者40名為對照組.採用ELISA法測定各組研究對象血清瘦素和脂聯素.結果 實驗組血清瘦素為(15.25±4.70) μg/L,較對照組[(6.15±1.70) g/L]增高,脂聯素為(7.39±1.92) mg/L,較對照組[(11.10±1.46) mg/L]降低,差異均有統計學意義(t值分彆為-11.696、11.216,P均＜0.01).無視網膜病變組、非增殖性視網膜病變組和增殖性視網膜病變組血清瘦素分彆為(10.91±1.21)、(15.22±3.75)、(20.50±3.70)μg/L;脂聯素分彆為(9.61±1.35)、(7.11±1.18)、(5.34±1.36) mg/L,各組間比較差異均有統計學意義(F值分彆為149.542、291.550,P均＜0.05).血清瘦素水平與血清脂聯素水平呈負相關(r=-0.662,P.＜0.01).結論 血清瘦素和脂聯素水平變化與糖尿病視網膜病變病變程度有關,二者可能成為糖尿病視網膜病變預測和療效評估的重要指標.
목적 탐토당뇨병시망막병변환자혈청수소화지련소수평적변화급기림상의의.방법 수집2012년11월지2013년11월재하북연합대학부속의원내분비과취진적2형당뇨병환자121례,기중당뇨병무시망막병변41례,비증식성시망막병변40례,증식성시망막병변40례,령설건강체검자40명위대조조.채용ELISA법측정각조연구대상혈청수소화지련소.결과 실험조혈청수소위(15.25±4.70) μg/L,교대조조[(6.15±1.70) g/L]증고,지련소위(7.39±1.92) mg/L,교대조조[(11.10±1.46) mg/L]강저,차이균유통계학의의(t치분별위-11.696、11.216,P균＜0.01).무시망막병변조、비증식성시망막병변조화증식성시망막병변조혈청수소분별위(10.91±1.21)、(15.22±3.75)、(20.50±3.70)μg/L;지련소분별위(9.61±1.35)、(7.11±1.18)、(5.34±1.36) mg/L,각조간비교차이균유통계학의의(F치분별위149.542、291.550,P균＜0.05).혈청수소수평여혈청지련소수평정부상관(r=-0.662,P.＜0.01).결론 혈청수소화지련소수평변화여당뇨병시망막병변병변정도유관,이자가능성위당뇨병시망막병변예측화료효평고적중요지표.
Objective To analyze the changes of leptin and adiponectin levels in serum of patients with diabetic retinopathy and investigate their chnical significance in diabetic retinopathy (DR).Methods One hundred and twenty-one patients with type 2 diabetes mellitus as the case group who hospitalized from Nov.2012 to Nov.2013.Among the patients,41 cases of non-DR,40 cases of nonproliferative-DR,40 cases of proliferativeDR.Forty healthy were served as the control group.The levels of leptin and adiponectin in serum were detected by Enzyme-Linked Immuno Sorbent Assay (ELISA).Results The overall levels of leptin in case group was (15.25 ± 4.70) μg/L,significantly higher than the control group ((6.15 ± 1.70) μg/L; t =-11.696,P ＜0.01)).The level of adiponectin in case group was (7.39 ± 1.92) mg/L,lower than the control group ((11.10 ± 1.46) mg/L; t =11.216,P ＜ 0.01).Moreover,the levels of leptin increased successively from (10.91 ±1.21) μg/L in NDR,(15.22 ±3.75) μg/ L in NPDR and (20.50 ±3.70) μg/L in PDR.While,the adiponectin levels decreased from (9.61 ± 1.35) mg/L in NDR,(7.11 ± 1.18) mg/L in NPDR and (5.34 ± 1.36) mg/L in PDR respectively.And the differences between the groups were significant(F =149,542,291,550;P ＜0.05).The levels of leptin and adiponectin in serum showed a negative correlation (r =-0.662,P ＜0.01).Condusion Levels of leptin and adiponectin in serum associate with DR,and both of them might be the important indexes for the prediction and curative effect evaluation of DR.
