CAJ | 학술논문

目的观察枸橼酸坦度螺酮治疗脑卒中后抑郁的临床效果和不良反应.方法选取来我院诊治的78例脑卒中后抑郁患者,随机分为治疗组40例和对照组38例.对照组给予常规治疗和心理治疗;治疗组在对照组治疗基础上给予枸橼酸坦度螺酮治疗,每次10 mg,3次/d口服.两组疗程均为4周.治疗前后进行汉密尔顿抑郁量表(HAMD)评分,并对其临床疗效和药物的不良反应进行观察比较.结果 (1)治疗组HAMD评分在治疗2周为(8.09±2.21)分,4周为(6.31±2.28)分,与治疗前[(11.98±2.17)分]比较明显下降,差异均有统计学意义(P均＜0.05);治疗2、4周与对照组[(10.57±2.53)分和(8.91±2.31)分]比较差异均有统计学意义(P均＜0.05).(2)对照组治疗总有效率为31.6％(12/38),治疗组为92.5％ (37/40),两组比较差异有统计学意义(x2=63.69,P＜0.01).(3)治疗过程中两组均未出现明显不良反应.结论枸橼酸坦度螺酮治疗脑卒中后抑郁效果明显,未见明显不良反应.
목적 관찰구연산탄도라동치료뇌졸중후억욱적림상효과화불량반응.방법 선취래아원진치적78례뇌졸중후억욱환자,수궤분위치료조40례화대조조38례.대조조급여상규치료화심리치료;치료조재대조조치료기출상급여구연산탄도라동치료,매차10 mg,3차/d구복.량조료정균위4주.치료전후진행한밀이돈억욱량표(HAMD)평분,병대기림상료효화약물적불량반응진행관찰비교.결과 (1)치료조HAMD평분재치료2주위(8.09±2.21)분,4주위(6.31±2.28)분,여치료전[(11.98±2.17)분]비교명현하강,차이균유통계학의의(P균＜0.05);치료2、4주여대조조[(10.57±2.53)분화(8.91±2.31)분]비교차이균유통계학의의(P균＜0.05).(2)대조조치료총유효솔위31.6％(12/38),치료조위92.5％ (37/40),량조비교차이유통계학의의(x2=63.69,P＜0.01).(3)치료과정중량조균미출현명현불량반응.결론 구연산탄도라동치료뇌졸중후억욱효과명현,미견명현불량반응.
Objective To investigate the clinical efficacy and side reaction of tandospimne citrate capsules on treating patients with depression after stroke.Methods Seventy-eight patients who were diagnosed as anxiety and depression after stroke were taken as our subjects.They were randomly divided into control group (n =40) and treatment group (n =38).Patients in the control group were given conventional therapy for cerebral vascular disease and psychological treatment,while in the treatment group were given the same treatment besides tandospimne citrate capsules of 10 mg per times,3 times/d oral,and course of both two groups for 4 weeks.The patients of two groups were scored according to Hamilton Depression Scale(HAMD) at the time of pre-treatment and post-treatment.And the the clinical efficacy and side reaction were observed and compared.Results (1) HAMD scores of treatment group in 2,4 weeks after treatment had significantly lower than that before treatment ((8.09±2.21) vs.(6.31 ±2.28) vs.(11.98 ±2.17),P ＜0.05).HAMD scores of control group in the treatment at 2week was as same as that in 4 weeks((10.57 ±2.53) vs.(8.91 ±2.31)).There was statistically significant difference in two groups in 2,4 weeks after treatment in terms of HAMD scores(P ＞0.05).The total effective rate of control group was 31.6％ (12/38),and 92.5％ (37/40) in treatment group,and the difference was significant(x2 =63.69,P ＜ 0.01).In the course of treatment in the two groups,there were no obvious adverse reactions.Conclusion Tandospirone citrate capsules show the clinical curative effect in the treatment of anxiety and depression after stroke,and no obvious adverse reactions.