中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
12期
1316-1318
,共3页
李培栋%单峤%吴建珩%刁玉领%武跃辉%王振%谢井伟%杨如意%王新军
李培棟%單嶠%吳建珩%刁玉領%武躍輝%王振%謝井偉%楊如意%王新軍
리배동%단교%오건형%조옥령%무약휘%왕진%사정위%양여의%왕신군
幕上胶质瘤%生活质量评分%生存率
幕上膠質瘤%生活質量評分%生存率
막상효질류%생활질량평분%생존솔
Supratentorial glioma%Quality of life score%Survival rate
目的 探讨幕上Ⅱ级胶质瘤患者的生存质量影响因素.方法 选择2010年3月至2013年2月我院经病理确诊的幕上Ⅱ级脑胶质瘤患者42例,均经开颅手术切除胶质瘤,手术前后分别对其进行生存质量KPS评分,并根据患者性别、年龄、术前存在神经功能障碍、癫痫史、肿瘤大小、肿瘤深浅等进行分类数据统计比较,研究患者生存质量的影响因素.结果 性别、术前神经功能障碍、癫痫史对患者生存质量无显著影响(P均＞0.05);年龄、肿瘤大小、肿瘤深浅和切除范围对患者生存质量存在影响,其中年龄≥60岁者手术前后生存质量评分差值显著低于＜60岁者[(12.8±4.8)、(20.6±8.7)分],肿瘤直径≥4 cm者手术前后生存质量评分差值显著低于＜4 cm者[(15.4±5.2)、(20.8±6.3)分],深部肿瘤者手术前后生存质量评分差值显著低于浅表肿瘤者[(13.8±6.2)、(21.2±4.8)分],次全切者手术前后生存质量评分差值显著低于全切者[14.3±5.8)、(19.8±6.3)分,差异均有统计学意义(t值分别为3.281、2.874、4.202、2.452,P均＜0.01或P＜0.05).42例患者随访时间(2.8±1.1)年,病死率7.1％(2/42),复发率28.6％(12/42).结论 幕上Ⅱ级胶质瘤患者的发展与生存情况与患者年龄、肿瘤大小、肿瘤深浅程度和手术切除范围等有关,高龄患者、肿瘤较大、较深以及次全切术式的患者其生存质量相对更差,应对该类患者格外重视,密切监视,综合提升手术效果.
目的 探討幕上Ⅱ級膠質瘤患者的生存質量影響因素.方法 選擇2010年3月至2013年2月我院經病理確診的幕上Ⅱ級腦膠質瘤患者42例,均經開顱手術切除膠質瘤,手術前後分彆對其進行生存質量KPS評分,併根據患者性彆、年齡、術前存在神經功能障礙、癲癇史、腫瘤大小、腫瘤深淺等進行分類數據統計比較,研究患者生存質量的影響因素.結果 性彆、術前神經功能障礙、癲癇史對患者生存質量無顯著影響(P均＞0.05);年齡、腫瘤大小、腫瘤深淺和切除範圍對患者生存質量存在影響,其中年齡≥60歲者手術前後生存質量評分差值顯著低于＜60歲者[(12.8±4.8)、(20.6±8.7)分],腫瘤直徑≥4 cm者手術前後生存質量評分差值顯著低于＜4 cm者[(15.4±5.2)、(20.8±6.3)分],深部腫瘤者手術前後生存質量評分差值顯著低于淺錶腫瘤者[(13.8±6.2)、(21.2±4.8)分],次全切者手術前後生存質量評分差值顯著低于全切者[14.3±5.8)、(19.8±6.3)分,差異均有統計學意義(t值分彆為3.281、2.874、4.202、2.452,P均＜0.01或P＜0.05).42例患者隨訪時間(2.8±1.1)年,病死率7.1％(2/42),複髮率28.6％(12/42).結論 幕上Ⅱ級膠質瘤患者的髮展與生存情況與患者年齡、腫瘤大小、腫瘤深淺程度和手術切除範圍等有關,高齡患者、腫瘤較大、較深以及次全切術式的患者其生存質量相對更差,應對該類患者格外重視,密切鑑視,綜閤提升手術效果.
목적 탐토막상Ⅱ급효질류환자적생존질량영향인소.방법 선택2010년3월지2013년2월아원경병리학진적막상Ⅱ급뇌효질류환자42례,균경개로수술절제효질류,수술전후분별대기진행생존질량KPS평분,병근거환자성별、년령、술전존재신경공능장애、전간사、종류대소、종류심천등진행분류수거통계비교,연구환자생존질량적영향인소.결과 성별、술전신경공능장애、전간사대환자생존질량무현저영향(P균＞0.05);년령、종류대소、종류심천화절제범위대환자생존질량존재영향,기중년령≥60세자수술전후생존질량평분차치현저저우＜60세자[(12.8±4.8)、(20.6±8.7)분],종류직경≥4 cm자수술전후생존질량평분차치현저저우＜4 cm자[(15.4±5.2)、(20.8±6.3)분],심부종류자수술전후생존질량평분차치현저저우천표종류자[(13.8±6.2)、(21.2±4.8)분],차전절자수술전후생존질량평분차치현저저우전절자[14.3±5.8)、(19.8±6.3)분,차이균유통계학의의(t치분별위3.281、2.874、4.202、2.452,P균＜0.01혹P＜0.05).42례환자수방시간(2.8±1.1)년,병사솔7.1％(2/42),복발솔28.6％(12/42).결론 막상Ⅱ급효질류환자적발전여생존정황여환자년령、종류대소、종류심천정도화수술절제범위등유관,고령환자、종류교대、교심이급차전절술식적환자기생존질량상대경차,응대해류환자격외중시,밀절감시,종합제승수술효과.
Objective To explore the risk factors of survival status of glioma patients with grade Ⅱ Screen.Methods Forty-two cases with brain glioma of Ⅱ cases diagnosed by pathology in the Fifth Affiliated Hospital of Zhengzhou University from Mar.2010 to Feb.2013 were enrolled in our study.All cases were performed glioma craniotomy operation.Survival quality score of KPS were calculated and classified according to the sex,age,preoperative neurological dysfunction,epilepsy history,tumor size,tumor depth.Studied the factors that influence the life quality of the patients.Results The indices of gender,preoperative neurological dysfunction and epilepsy history had not impacted on quality of life (P ＞ 0.05).However,the factors of age,tumor size,the depth and extent of resection affected the quality of life.KPS of patients more than 60 years was (12.8 ± 4.8),lower than that less than 60 years old (20.6 ± 8.7).KPS of patients with tumor diameter greater than or equal to 4 cm were (15.4 ± 5.2),less than that tumor diameter smaller than 4 cm (20.8 ± 6.3).KPS of patients with deep tumor,subtotal incision were (13.8 ± 6.2) and (14.3 ±5.8),lower than those of patients with superficial tumors and total resection ((21.2 ± 4.8),(19.8 ± 6.3)).The differences were significant(t =3.281,2.874,4.202,2.452 ; P ＜ 0.01 or P ＜ 0.05).All patients were followed up for (2.8± 1.1) years.The mortality rate was 7.1％ (2/42),and the relapse rate was 28.6％ (12/42).Conclusion The development and survival of patients with supratentorial Ⅱ glioma are related to age,tumor size,extent of resection range.Patients with older age,larger tumor size,deeper and subtotal resection have the worse quality of life.It should be done including paying more attention for this kinds of cases,monitoring frequency and improving the effect of comprehensive operation.
