中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2014年
12期
1437-1440
,共4页
真菌性角膜溃疡%透明质酸钠%药物治疗%显微病灶切除
真菌性角膜潰瘍%透明質痠鈉%藥物治療%顯微病竈切除
진균성각막궤양%투명질산납%약물치료%현미병조절제
Fungal keratitis%Microsurgical resection of lesions%Sodium hyaluronate%Visual acuity%Treatment time
目的 探讨病灶显微切除联合透明质酸钠点眼在真菌性角膜溃疡治疗中的效果.方法 临床病例对照研究.对2006年至1012年12月在解放军第180医院眼科中心回顾性分析接受治疗的真菌性角膜溃疡患者211例211只眼.其中130例130只眼作为治疗组,在接受传统抗真菌治疗基础上,予病灶显微切除清除溃疡表面坏死组织,并予玻璃酸钠眼液点眼促进溃疡愈合;另外81例81只眼作为对照组,仅接受与治疗组相同的传统抗真菌治疗.对比分析两组的住院时间、治愈好转率及最终视力.结果 治疗组平均住院时间(12.15±5.23)d,治愈122例,治愈率93.85％ (122/130),好转5例,占3.85％,无效3例,占2.31％,最终视力＞0.3者79例,占60.77％ (97/130).对照组平均住院时间(17.26±6.23)d,治愈69例,治愈率85.19％ (69/81),好转9例,占11.11％,无效3例,占3.70％,最终视力＞0.3者32例,占39.51％ (32/81).经统计学分析,治疗组的住院时间短于对照组,治愈率、最终视力均高于对照组,差异具有统计学意义(P＜0.05),两组的有效率差异无统计学意义(P＞0.05).结论 病灶显微切除联合玻璃酸钠点眼可促进真菌性角膜溃疡愈合,缩短治疗时间,减少角膜瘢痕,提高治愈率和最终视力.
目的 探討病竈顯微切除聯閤透明質痠鈉點眼在真菌性角膜潰瘍治療中的效果.方法 臨床病例對照研究.對2006年至1012年12月在解放軍第180醫院眼科中心迴顧性分析接受治療的真菌性角膜潰瘍患者211例211隻眼.其中130例130隻眼作為治療組,在接受傳統抗真菌治療基礎上,予病竈顯微切除清除潰瘍錶麵壞死組織,併予玻璃痠鈉眼液點眼促進潰瘍愈閤;另外81例81隻眼作為對照組,僅接受與治療組相同的傳統抗真菌治療.對比分析兩組的住院時間、治愈好轉率及最終視力.結果 治療組平均住院時間(12.15±5.23)d,治愈122例,治愈率93.85％ (122/130),好轉5例,佔3.85％,無效3例,佔2.31％,最終視力＞0.3者79例,佔60.77％ (97/130).對照組平均住院時間(17.26±6.23)d,治愈69例,治愈率85.19％ (69/81),好轉9例,佔11.11％,無效3例,佔3.70％,最終視力＞0.3者32例,佔39.51％ (32/81).經統計學分析,治療組的住院時間短于對照組,治愈率、最終視力均高于對照組,差異具有統計學意義(P＜0.05),兩組的有效率差異無統計學意義(P＞0.05).結論 病竈顯微切除聯閤玻璃痠鈉點眼可促進真菌性角膜潰瘍愈閤,縮短治療時間,減少角膜瘢痕,提高治愈率和最終視力.
목적 탐토병조현미절제연합투명질산납점안재진균성각막궤양치료중적효과.방법 림상병례대조연구.대2006년지1012년12월재해방군제180의원안과중심회고성분석접수치료적진균성각막궤양환자211례211지안.기중130례130지안작위치료조,재접수전통항진균치료기출상,여병조현미절제청제궤양표면배사조직,병여파리산납안액점안촉진궤양유합;령외81례81지안작위대조조,부접수여치료조상동적전통항진균치료.대비분석량조적주원시간、치유호전솔급최종시력.결과 치료조평균주원시간(12.15±5.23)d,치유122례,치유솔93.85％ (122/130),호전5례,점3.85％,무효3례,점2.31％,최종시력＞0.3자79례,점60.77％ (97/130).대조조평균주원시간(17.26±6.23)d,치유69례,치유솔85.19％ (69/81),호전9례,점11.11％,무효3례,점3.70％,최종시력＞0.3자32례,점39.51％ (32/81).경통계학분석,치료조적주원시간단우대조조,치유솔、최종시력균고우대조조,차이구유통계학의의(P＜0.05),량조적유효솔차이무통계학의의(P＞0.05).결론 병조현미절제연합파리산납점안가촉진진균성각막궤양유합,축단치료시간,감소각막반흔,제고치유솔화최종시력.
Objective To analyze the effect of repeated microscopic lesion excision combined with sodium hyaluronate eye drop in the treatment of fungal corneal ulcer.Methods A retrospective analysis of 211 cases (211 eyes) of fungal corneal ulcer in our hospital,130 cases (130 eyes) selected as the treatment group received repeated microscopic lesion excision to remove necrotic tissue of ulcer surface,and sodium hyaluronate eye drops to promote ulcer healing,based on conventional antifungal therapy; 81 cases (81 eyes) as a control group received only the conventional antifungal treatment.The average hospital stay,the cure rate,effective rate and final visual acuity of two groups were comparative analyzed.Results On 130 cases of the treatment group,the average hospital stay was 12.15±5.23d,122 cases were cured,the cure rate 93.85％,5 cases improved,accounted for 3.85％,3 cases were ineffective,accounted for 2.31％,79 cases' final visual acuity ＞ 0.3,accounted for 60.77％.On 81 cases of the control group,average hospital stay was 17.26 ± 6.23d,69 cases were cured,the cure rate 85.19％,improved in 9 cases,accounted for 11.11％,3 cases ineffective,accounted for 3.70％,32 cases' final visual acuity ＞0.3,accounted for 39.51％.After statistical analysis,the average hospital stay of the treatment group was shorter than that of the control group,the cure rate and final visual acuity were higher,the difference was statistically significant (P ＜0.05),the two groups had no significant difference in effective rate (P ＞0.05).Conclusions Repeated microsurgical resection of lesions combined with sodium hyaluronate eye drop can promote fungal corneal ulcer healing,shorten treatment time and reduce corneal scarring,improve the cure rate and final visual acuity.
