CAJ | 학술논문

目的探讨富含半胱氨酸的酸性分泌蛋白(SPARC)对2型糖尿病视网膜病变(DR)的影响.方法临床病例对照研究.对2013年6～12月,在保定市第一中心医院,通过眼底荧光造影或眼底照相检查,将100例2型糖尿病患者分为2组:糖尿病不伴视网膜病变组(NDR) 38例;背景型视网膜病变组(BDR组)31例;增生型视网膜病变组(PDR组)31例.选取健康体检者42名作为对照组(CON组).检测血清SPARC浓度及空腹血糖(FBG)、糖化血红蛋白(HbA1C)、血脂等.结果糖尿病视网膜病变组血清SPARC水平(18.98+3.35) μg/L高于糖尿病不伴视网膜病变组(16.26+2.07) μg/L及对照组(14.85+2.05) μg/L,差异有统计学意义(F=22.04,P＜0.01).增生型视网膜病变组血清SPARC水平(19.86+3.60) μg/L高于背景型视网膜病变组(17.88+3.19) μg/L,差异有统计学意义(t =3.57,P＜0.01).多元回归分析显示:LDL-C、FBG、HbA1C是血清SPARC的独立危险因素.结论血清SPARC是糖尿病视网膜病变发生的危险因素.
목적 탐토부함반광안산적산성분비단백(SPARC)대2형당뇨병시망막병변(DR)적영향.방법 림상병례대조연구.대2013년6～12월,재보정시제일중심의원,통과안저형광조영혹안저조상검사,장100례2형당뇨병환자분위2조:당뇨병불반시망막병변조(NDR) 38례;배경형시망막병변조(BDR조)31례;증생형시망막병변조(PDR조)31례.선취건강체검자42명작위대조조(CON조).검측혈청SPARC농도급공복혈당(FBG)、당화혈홍단백(HbA1C)、혈지등.결과 당뇨병시망막병변조혈청SPARC수평(18.98+3.35) μg/L고우당뇨병불반시망막병변조(16.26+2.07) μg/L급대조조(14.85+2.05) μg/L,차이유통계학의의(F=22.04,P＜0.01).증생형시망막병변조혈청SPARC수평(19.86+3.60) μg/L고우배경형시망막병변조(17.88+3.19) μg/L,차이유통계학의의(t =3.57,P＜0.01).다원회귀분석현시:LDL-C、FBG、HbA1C시혈청SPARC적독립위험인소.결론 혈청SPARC시당뇨병시망막병변발생적위험인소.
Objective To discuss the influence of serum secreted protein acidic and rich in cysteine (SPARC) on the pathogenesis of diabetic retinopathy (DR).Methods All the patients had routine FFA and examination of fundus photos.A total of 100 patients of T2DM were divided into three groups:No signs of diabetic retinopathy (NDR group n=38),Background DR (BDR group n=31),proliferative DR (PDR group n=31).Forty-two persons were served as control group (CON group).The serum levels of SPARC,fasting blood glucose,glycosylated hemoglobin and the blood lipids were measured.Results Serum SPARC levels were significantly higher in DR group than those in NDR group and CON group.In DR group,serum SPARC levels in PDR group were significantly higher than that in BDR group.By stepwise regression analysis,LDL-C,FBG,HbA1C were independent risk factors for serum SPARC level in type 2 diabetes.Conclusions The serum SPARC may be a risk factor for the occurrence of DR.