中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2014年
12期
1457-1459
,共3页
翼状胬肉%白体角膜缘干细胞移植%单纯切除
翼狀胬肉%白體角膜緣榦細胞移植%單純切除
익상노육%백체각막연간세포이식%단순절제
Pterygium%Autologous limbal stem cell transplantation%Simple pterygium excision
目的 通过对联合白体角膜缘干细胞移植术和单纯切除术治疗翼状胬肉的临床疗效的比较,评价两种手术方式的治疗效果.方法 临床病例对照研究.对201 1年1月至2013年12月在信阳职业技术学院附属医院眼科就诊的136例(169只眼)翼状胬肉患者,原发性108例(137只眼),复发性28例(32只眼).按随机表顺序分为A组和B组.A组68例(84只眼)采用翼状胬肉单纯切除术;B组68例(85只眼)采用翼状胬肉切除联合自体角膜缘干细胞移植术,术后随访6～18个月.A组失访5例(5只眼),B组失访4例(4只眼).结果 角膜创面上皮愈合时间:A组为5～9 (6.3±1.3)d;B组为3～5(3.9±1.2)d,两组比较差异有统计学意义(t =3.318,P＜0.05).A组16只眼复发,复发率为20.25％ (16/79);B组3只眼复发,复发率为3.70％(3/81),两组比较差异有统计学意义(x2=4.39,P ＜0.05).结论 联合白体角膜缘干细胞移植术治疗翼状胬肉可以缩短角膜创面上皮愈合时间,降低复发率,是一种有效安全地治疗方法,值得推广运用.
目的 通過對聯閤白體角膜緣榦細胞移植術和單純切除術治療翼狀胬肉的臨床療效的比較,評價兩種手術方式的治療效果.方法 臨床病例對照研究.對201 1年1月至2013年12月在信暘職業技術學院附屬醫院眼科就診的136例(169隻眼)翼狀胬肉患者,原髮性108例(137隻眼),複髮性28例(32隻眼).按隨機錶順序分為A組和B組.A組68例(84隻眼)採用翼狀胬肉單純切除術;B組68例(85隻眼)採用翼狀胬肉切除聯閤自體角膜緣榦細胞移植術,術後隨訪6～18箇月.A組失訪5例(5隻眼),B組失訪4例(4隻眼).結果 角膜創麵上皮愈閤時間:A組為5～9 (6.3±1.3)d;B組為3～5(3.9±1.2)d,兩組比較差異有統計學意義(t =3.318,P＜0.05).A組16隻眼複髮,複髮率為20.25％ (16/79);B組3隻眼複髮,複髮率為3.70％(3/81),兩組比較差異有統計學意義(x2=4.39,P ＜0.05).結論 聯閤白體角膜緣榦細胞移植術治療翼狀胬肉可以縮短角膜創麵上皮愈閤時間,降低複髮率,是一種有效安全地治療方法,值得推廣運用.
목적 통과대연합백체각막연간세포이식술화단순절제술치료익상노육적림상료효적비교,평개량충수술방식적치료효과.방법 림상병례대조연구.대201 1년1월지2013년12월재신양직업기술학원부속의원안과취진적136례(169지안)익상노육환자,원발성108례(137지안),복발성28례(32지안).안수궤표순서분위A조화B조.A조68례(84지안)채용익상노육단순절제술;B조68례(85지안)채용익상노육절제연합자체각막연간세포이식술,술후수방6～18개월.A조실방5례(5지안),B조실방4례(4지안).결과 각막창면상피유합시간:A조위5～9 (6.3±1.3)d;B조위3～5(3.9±1.2)d,량조비교차이유통계학의의(t =3.318,P＜0.05).A조16지안복발,복발솔위20.25％ (16/79);B조3지안복발,복발솔위3.70％(3/81),량조비교차이유통계학의의(x2=4.39,P ＜0.05).결론 연합백체각막연간세포이식술치료익상노육가이축단각막창면상피유합시간,강저복발솔,시일충유효안전지치료방법,치득추엄운용.
Objective To compare the clinical efficacy of pterygium treaded by combined with autologous limbal stem cell transplantation and simple pterygium excision,and to evaluate the therapeutic effects,safety and feasibility of two different surgery.Methods One hundred and thirty-six cases (169 eyes) with pterygium were randomly assigned into 2 groups and operated,108 cases (137 eyes) were primary and 28 cases (32 eyes) were recurrent pterygium.Simple pterygium excision (group A) was adopted in 84 eyes of 68 cases.Limbal stem cell transplantation (group B) was adopted in 85 eyes of 68 cases.The postoperative follow-up periods were 6 to 18 months.Results The average epithelial recovering time of corneal wound was 6.3 days and 3.9 days,respectively,the difference was statistical significant (t =3.318,P ＜0.05).Recurrence of 22 eyes was noted in simple pterygium excision group (group A),the recurrent rate was 20.25％,however recurrence of 3 eyes was noted in limbal stem cell transplantation group (group A),and the recurrent rate was 3.70％.There was statistical significant difference between two groups (x2=4.39,P ＜0.05).Conclusions Combined with autologous limbal stem cell transplantation can improve epithelial recovering time of corneal wound and decrease the recurrent rate.It is an effective and safe method for treating the pterygium and is worth to spreading.
