低浓度饮水型砷暴露对人群外周血血细胞参数的影响
저농도음수형신폭로대인군외주혈혈세포삼수적영향
Influence of low level arsenic exposure through drinking water on human peripheral blood cells
  • 万方数据
    中华地方病学杂志 중화지방병학잡지
    Chinese Journal of Endemiology
    2015年 1期 29-32 ,共4页

    马彩凤%云奋%安全%李云云%苗艳玲%田凤洁%吕懿%秦秀军%刘力

    마채봉%운강%안전%리운운%묘염령%전봉길%려의%진수군%류력

    砷%流行病学%血细胞 砷%流行病學%血細胞
    신%류행병학%혈세포
    Arsenic%Epidemiology%Blood cells
    目的 分析低浓度饮水型砷暴露对人群外周血血细胞的影响,为筛选低浓度砷暴露的早期损伤标志提供依据.方法 在山西省大同市,选择相邻且经济发展均衡的地方性砷中毒(简称地砷病)病区(水砷含量为14.41 ～ 90.34 μg/L)和非地砷病病区(水砷含量为0.00～ 0.87 μg/L),在病区与非病区各选择1个自然村,抽取饮当地水15年以上本地居民,无传染性、遗传性等疾病,无放射线和理化致病因素接触史者为调查对象.其中地砷病病区85名,为砷暴露组;非地砷病病区71名,为对照组.采集静脉血,全自动血细胞分析仪测定血细胞参数的变化.结果 白细胞各项指标:砷暴露组淋巴细胞绝对值[LYM,(2.00±0.90)×109/L]和淋巴细胞百分比[LYM％,(33.92±9.70)％]均高于对照组[(1.58±0.57)×109/L,(29.72±8.32)％,t值分别为-3.348、-2.873,P均＜0.05],单核细胞绝对值[MON,(0.15±0.07)×109/L]、单核细胞百分比[MON％,(2.53±0.77)％]均低于对照组[(0.47±0.15)×109/L,(8.64±1.97)％,t值分别为16.309、24.599,P均＜0.05].红细胞各项指标:砷暴露组红细胞[RBC,(4.44±0.46)×109/L]、血红蛋白[HGB,(136.59±13.84)g/L]、平均红细胞血红蛋白含量[MCH,(30.85±1.87)pg]、平均红细胞血红蛋白浓度[MCHC,(360.67±8.54)g/L]和红细胞体积分布宽度[RDW,(13.19±0.75)％]均高于对照组[(4.10±0.58)×109/L,(111.11±16.49)g/L,(27.68±2.99)pg,(295.20±36.82)g/L,(11.06±1.08)％,t值分别为-4.063、-10.491、-7.747、-14.651、-14.450,P均＜0.05],平均红细胞体积[MCV,(85.49±4.43)fl]则低于对照组[(92.69±7.50)fl,t=7.114,P＜ 0.05].血小板各项指标:砷暴露组血小板[PLT,(217.11±49.36)×109/L]、平均血小板体积[MPV,(7.01±1.16)fl]和血小板压积[PCT,(0.15±0.04)L/L]均低于对照组[(259.30±74.97)×109/L,(11.27±1.31)fl,(0.28±0.08) L/L,t值分别为4.073、21.486、13.428,P均＜0.05],血小板分布宽度[PDW,(18.21±0.55)％]高于对照组[(9.23±2.29)％,t=-32.228,P＜ 0.05].结论 长期低浓度饮水型砷暴露能引起人群外周血血细胞参数的改变.RBC增加,HGB含量升高,PLT数目明显减少,PLT和RBC体积异质性增加.
    목적 분석저농도음수형신폭로대인군외주혈혈세포적영향,위사선저농도신폭로적조기손상표지제공의거.방법 재산서성대동시,선택상린차경제발전균형적지방성신중독(간칭지신병)병구(수신함량위14.41 ～ 90.34 μg/L)화비지신병병구(수신함량위0.00～ 0.87 μg/L),재병구여비병구각선택1개자연촌,추취음당지수15년이상본지거민,무전염성、유전성등질병,무방사선화이화치병인소접촉사자위조사대상.기중지신병병구85명,위신폭로조;비지신병병구71명,위대조조.채집정맥혈,전자동혈세포분석의측정혈세포삼수적변화.결과 백세포각항지표:신폭로조림파세포절대치[LYM,(2.00±0.90)×109/L]화림파세포백분비[LYM％,(33.92±9.70)％]균고우대조조[(1.58±0.57)×109/L,(29.72±8.32)％,t치분별위-3.348、-2.873,P균＜0.05],단핵세포절대치[MON,(0.15±0.07)×109/L]、단핵세포백분비[MON％,(2.53±0.77)％]균저우대조조[(0.47±0.15)×109/L,(8.64±1.97)％,t치분별위16.309、24.599,P균＜0.05].홍세포각항지표:신폭로조홍세포[RBC,(4.44±0.46)×109/L]、혈홍단백[HGB,(136.59±13.84)g/L]、평균홍세포혈홍단백함량[MCH,(30.85±1.87)pg]、평균홍세포혈홍단백농도[MCHC,(360.67±8.54)g/L]화홍세포체적분포관도[RDW,(13.19±0.75)％]균고우대조조[(4.10±0.58)×109/L,(111.11±16.49)g/L,(27.68±2.99)pg,(295.20±36.82)g/L,(11.06±1.08)％,t치분별위-4.063、-10.491、-7.747、-14.651、-14.450,P균＜0.05],평균홍세포체적[MCV,(85.49±4.43)fl]칙저우대조조[(92.69±7.50)fl,t=7.114,P＜ 0.05].혈소판각항지표:신폭로조혈소판[PLT,(217.11±49.36)×109/L]、평균혈소판체적[MPV,(7.01±1.16)fl]화혈소판압적[PCT,(0.15±0.04)L/L]균저우대조조[(259.30±74.97)×109/L,(11.27±1.31)fl,(0.28±0.08) L/L,t치분별위4.073、21.486、13.428,P균＜0.05],혈소판분포관도[PDW,(18.21±0.55)％]고우대조조[(9.23±2.29)％,t=-32.228,P＜ 0.05].결론 장기저농도음수형신폭로능인기인군외주혈혈세포삼수적개변.RBC증가,HGB함량승고,PLT수목명현감소,PLT화RBC체적이질성증가.
    Objective To analyze the impact of low concentrations of arsenic exposure on peripheral blood cells in human being,and to provide a basis for screening early damage indicators of arsenic exposure.Methods In Datong City Shanxi Province,two neighboring districts with and without endemic arsenism were selected,in which economic development was balanced.The arsenic contents in drinking water of the two districts were 14.41-90.34 and 0.00-0.87 μg/L,respectively.One natural village in each district was selected.Aborigines (drinking local water for 15 or more years consecutively) were selected as research subjects (85 people as exposed group and 71 people as control group).All of the candidates had neither infectious nor genetic diseases nor contacted radiation and physicochemical factors which may cause the disease.Venous blood was collected and automatic blood cell analyzer was used to analyze the changes of blood parameters.Results Compared with the control group [lymphocyte (LYM):(1.58 ± 0.57) × 109/L,lymphocyte percentage (LYM％):(29.72 ± 8.32)％,mononuclear cell (MON):(0.47 ± 0.15) × 109/L,mononuclear cell percentage (MON％):(8.64 ± 1.97)％; red blood cell(RBC):(4.10 ± 0.58) × 109/L,hemoglobin (HGB):(111.11 ± 16.49)g/L,mean corpuscular hemoglobin (MCH):(27.68 ± 2.99)pg,mean corpuscular hemoglobin concentration (MCHC):(295.20 ± 36.82)g/L,red distribution width (RDW):(11.06 ± 1.08)％,mean cell volume (MCV):(92.69 ± 7.50)fl; platelet(PLT):(259.30 ± 74.97) × 109/L,mean platelet volume (MPV):(11.27 ± 1.31)fl,platelet deposited (PCT):(0.28 ± 0.08)L/L,platelet volume width (PDW):(9.23 ± 2.29)％],some blood parameters had been changed in arsenic poisoning group:① LYM [(2.00 ± 0.90) × 109/L] and LYM％ [(33.92 ± 9.70)％] were increased (t =-3.348,-2.873,all P ＜ 0.05); MON[(0.15 ± 0.07) × 109/L],MON％[(2.53 ± 0.77)％] were decreased (t =16.309,24.599,all P ＜ 0.05); ②RBC [(4.44 ± 0.46) × 109/L],HGB [136.59 ± 13.84)g/L],MCH [(30.85 ± 1.87)pg],MCHC [(360.67 ± 8.54)g/L] and RDW [(13.19 ± 0.75)％] were increased (t =-4.063,-10.491,-7.747,-14.651,-14.450,all P ＜ 0.05),and MCV [(85.49 ± 4.43)fl] was reduced significantly (t =7.114,P＜ 0.05); ③ Every index of PLT [(217.11 ± 49.36) × 109/L],MPV [(7.01 ± 1.16)] and PCT [(0.15 ± 0.64)L/L] showed an obvious declining trend,and the differences were statistically significant (t =4.073,21.486,13.428,all P ＜ 0.05); PDW[(18.21 ± 0.55)％] showed a rising trend,and the difference was statistically significant (t =-3 2.228,P ＜ 0.05).Conclusions Long-term exposure to low concentrations of arsenic can cause changes in peripheral blood cells.The number of RBC has increased,HGB levels increased,and the number of PLT has decreased significantly.At the same time,the volume heterogeneity of PLT and RBC hasincreased.
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