中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
36期
23-27
,共5页
复发%辅酶Q10%阿弗他溃疡
複髮%輔酶Q10%阿弗他潰瘍
복발%보매Q10%아불타궤양
Recurrence%Coenzyme Q10%Aphthous ulcer
目的 观察还原型辅酶Q10治疗重型复发性阿弗他溃疡(RAU)的临床疗效.方法 将64例重型RAU患者按随机数字表法分为试验组(30例)与对照组(34例).对照组予以常规治疗,试验组在对照组的基础上口服辅酶Q10,观察相关临床指标差异性.结果 与入院时比较,试验组入院2周汉密尔顿焦虑量表(HAMA量表)、疾病不确定量表(MUIS量表)、目测模拟疼痛程度指数(VAS指数)的评分显著降低,差异有统计学意义(P＜0.05);与对照组入院2周比较,试验组MUIS量表、VAS指数的评分显著降低,差异有统计学意义(P＜0.05);与入院时比较,试验组入院2周超氧化物歧化酶、CD4+、CD4+/CD5+显著升高,差异有统计学意义(P＜0.05),丙二醛(MAD)、纤维蛋白原含量显著降低,差异有统计学意义(P＜0.05);与对照组入院2周比较,试验组MAD含量显著降低,CD4+、CD4+/CD5+显著升高,差异有统计学意义(P＜0.05);与对照组比较,试验组溃疡持续时间明显缩短[(13.75±3.58)d比(16.89±5.17)d],差异有统计学意义(P＜0.05);与对照组比较,试验组的起效率明显增加、无效率明显下降、总有效率明显增加,差异均有统计学意义(P＜0.05).结论 辅酶Q10治疗重型RAU疗效确切,值得临床推广.
目的 觀察還原型輔酶Q10治療重型複髮性阿弗他潰瘍(RAU)的臨床療效.方法 將64例重型RAU患者按隨機數字錶法分為試驗組(30例)與對照組(34例).對照組予以常規治療,試驗組在對照組的基礎上口服輔酶Q10,觀察相關臨床指標差異性.結果 與入院時比較,試驗組入院2週漢密爾頓焦慮量錶(HAMA量錶)、疾病不確定量錶(MUIS量錶)、目測模擬疼痛程度指數(VAS指數)的評分顯著降低,差異有統計學意義(P＜0.05);與對照組入院2週比較,試驗組MUIS量錶、VAS指數的評分顯著降低,差異有統計學意義(P＜0.05);與入院時比較,試驗組入院2週超氧化物歧化酶、CD4+、CD4+/CD5+顯著升高,差異有統計學意義(P＜0.05),丙二醛(MAD)、纖維蛋白原含量顯著降低,差異有統計學意義(P＜0.05);與對照組入院2週比較,試驗組MAD含量顯著降低,CD4+、CD4+/CD5+顯著升高,差異有統計學意義(P＜0.05);與對照組比較,試驗組潰瘍持續時間明顯縮短[(13.75±3.58)d比(16.89±5.17)d],差異有統計學意義(P＜0.05);與對照組比較,試驗組的起效率明顯增加、無效率明顯下降、總有效率明顯增加,差異均有統計學意義(P＜0.05).結論 輔酶Q10治療重型RAU療效確切,值得臨床推廣.
목적 관찰환원형보매Q10치료중형복발성아불타궤양(RAU)적림상료효.방법 장64례중형RAU환자안수궤수자표법분위시험조(30례)여대조조(34례).대조조여이상규치료,시험조재대조조적기출상구복보매Q10,관찰상관림상지표차이성.결과 여입원시비교,시험조입원2주한밀이돈초필량표(HAMA량표)、질병불학정량표(MUIS량표)、목측모의동통정도지수(VAS지수)적평분현저강저,차이유통계학의의(P＜0.05);여대조조입원2주비교,시험조MUIS량표、VAS지수적평분현저강저,차이유통계학의의(P＜0.05);여입원시비교,시험조입원2주초양화물기화매、CD4+、CD4+/CD5+현저승고,차이유통계학의의(P＜0.05),병이철(MAD)、섬유단백원함량현저강저,차이유통계학의의(P＜0.05);여대조조입원2주비교,시험조MAD함량현저강저,CD4+、CD4+/CD5+현저승고,차이유통계학의의(P＜0.05);여대조조비교,시험조궤양지속시간명현축단[(13.75±3.58)d비(16.89±5.17)d],차이유통계학의의(P＜0.05);여대조조비교,시험조적기효솔명현증가、무효솔명현하강、총유효솔명현증가,차이균유통계학의의(P＜0.05).결론 보매Q10치료중형RAU료효학절,치득림상추엄.
Objective To observe the curative effect of reduced coenzyme Q10 in treatment of severe recurrent aphthous ulcer (RAU).Methods A total of 64 severe RAU patients were divided into experimental group (30 cases) and control group (34 cases) by random digits table method.The control group received conventional treatment,and the experimental group was treated with coenzyme Q10 on the basis of the control group.The clinical indicators were observed.Results Compared to patients on admission,the Hamilton Anxiety Scale (HAMA scale),disease uncertainty Scale (MUIS scale),visual analog pain scale (VAS index) after 2 weeks in hospital in the experimental group were decreased,and there were significant differences (P ＜ 0.05).Compared to the control group after 2 weeks in hospital,MUIS scale,VAS index were decreased in the experimental group,and there were significant differences (P ＜ 0.05).Compared to patients on admission,superoxide dismutase,CD4+,CD4+/CD5+ after 2 weeks in hospital in the experimental group were increased,malondialdehyde (MAD),fibrinogen were decreased,and there were significant differences (P ＜0.05).Compared to the control group after 2 weeks in hospital,MAD was decreased,CD4+,CD4+/CD5+ were increased in the experimental group,and there were significant differences (P ＜0.05).Compared to the control group,the ulcer duration in the experimental group was shorter [(13.75 ± 3.58) d vs.(16.89 ± 5.17) d],and there was significant difference (P ＜ 0.05).Compared to the control group,the efficiency was increased,the no efficiency was decreased,the total efficiency was increased,and there was significant difference (P ＜ 0.05).Conclusion Coenzyme Q10 is effective in treatment of severe RAU,worthy of promotion.
