CAJ | 학술논문

目的探讨亚临床甲状腺功能减退症(SCH)与2型糖尿病患者发生微量白蛋白尿之间的关系.方法纳入826例无已知甲状腺疾病且未接受相关治疗的2型糖尿病患者,评估患者的血糖控制情况、甲状腺功能及微量白蛋白尿的患病率.结果 826例患者中合并SCH患者46例(5.56％,46/826),甲状腺功能正常患者780例(94.44％,780/826),合并SCH患者中女性患者的比例及体质量指数高于甲状腺功能正常患者[69.6％ (32/46)比49.7％(388/780)、(26.7±4.0)kg/m2比(25.1±3.8) kg/m2],差异有统计学意义(P＜0.01).合并SCH患者与甲状腺功能正常患者糖化血红蛋白水平比较差异无统计学意义(P＞0.05);合并SCH患者与甲状腺功能正常患者微量白蛋白尿的患病率差异无统计学意义(P＞0.05).结论 SCH不是2型糖尿病患者发生微量白蛋白尿的危险因素.
목적 탐토아림상갑상선공능감퇴증(SCH)여2형당뇨병환자발생미량백단백뇨지간적관계.방법 납입826례무이지갑상선질병차미접수상관치료적2형당뇨병환자,평고환자적혈당공제정황、갑상선공능급미량백단백뇨적환병솔.결과 826례환자중합병SCH환자46례(5.56％,46/826),갑상선공능정상환자780례(94.44％,780/826),합병SCH환자중녀성환자적비례급체질량지수고우갑상선공능정상환자[69.6％ (32/46)비49.7％(388/780)、(26.7±4.0)kg/m2비(25.1±3.8) kg/m2],차이유통계학의의(P＜0.01).합병SCH환자여갑상선공능정상환자당화혈홍단백수평비교차이무통계학의의(P＞0.05);합병SCH환자여갑상선공능정상환자미량백단백뇨적환병솔차이무통계학의의(P＞0.05).결론 SCH불시2형당뇨병환자발생미량백단백뇨적위험인소.
Objective To determine the relationship between subclinical hypothyroidism (SCH) and the prevalence of albuminuria in type 2 diabetes mellitus.Methods A total of 826 type 2 diabetes mellitus patients without thyroid disease were enrolled.Participants were evaluated for glycemic control,thyroid function,and albuminuria in a cross-sectional analysis.Results Of 826 type 2 diabetes mellitus,780 subjects were euthyroid(94.44％,780/826) and 46 had SCH (5.56％,46/826).The patients with SCH had a higher proportion in women and higher body mass index compared with the patients with euthyroid [69.6％(32/46) vs.49.7％(388/780),(26.7 ± 4.0) kg/m2 vs.(25.1 ± 3.8) kg/m2],and there was significant difference(P ＜ 0.01).No significant difference in glycated hemoglobin and the prevalence of albuminuria was found between the patients with SCH and the patients with euthyroid (P ＞ 0.05).Conclusion SCH is not a risk factor for albuminuria in type 2 diabetes mellitus.