CAJ | 학술논문

目的观察医用三氧联合吉西他滨、顺铂(GP)方案治疗晚期非小细胞肺癌的疗效及不良反应.方法共55例晚期非小细胞肺癌患者均采用GP方案化疗,其中对照组27例,观察组28例加用三氧治疗,比较两组近期疗效、生存质量、不良反应及细胞免疫功能情况.结果两组患者疗效比较差异无统计学意义(P＞0.05);治疗后患者生存质量评分观察组优于对照组,差异有统计学意义(P＜0.05),观察组治疗后肝功能损伤低于对照组,差异有统计学意义(P＜0.05),观察组治疗后的细胞免疫功能较对照组明显增强,差异有统计学意义(P＜0.05).结论医用三氧联合GP方案治疗晚期非小细胞肺癌,在改善症状、提高患者生存质量、增强细胞免疫功能方面具有较好的优势.
목적 관찰의용삼양연합길서타빈、순박(GP)방안치료만기비소세포폐암적료효급불량반응.방법 공55례만기비소세포폐암환자균채용GP방안화료,기중대조조27례,관찰조28례가용삼양치료,비교량조근기료효、생존질량、불량반응급세포면역공능정황.결과 량조환자료효비교차이무통계학의의(P＞0.05);치료후환자생존질량평분관찰조우우대조조,차이유통계학의의(P＜0.05),관찰조치료후간공능손상저우대조조,차이유통계학의의(P＜0.05),관찰조치료후적세포면역공능교대조조명현증강,차이유통계학의의(P＜0.05).결론 의용삼양연합GP방안치료만기비소세포폐암,재개선증상、제고환자생존질량、증강세포면역공능방면구유교호적우세.
Objective To observe the efficacy and adverse reaction of ozone therapy combined with gemcitabine and cisplatin (GP) regimen in patients with advanced non-small cell lung cancer.Methods Fifty-five patients with advanced non-small cell lung cancer were enrolled and allocated to treatment group (28 cases) and control group (27 cases).The patients in treatment group received ozone therapy combined with GP regimen,and the patients in control group received GP regimen only.The efficacy,quality of life,adverse reaction and cellular immune function after treatment was compared between two groups.Results There was no significant difference in the efficacy between two groups (P ＞ 0.05).The quality of life after treatment in treatment group was better than that in control group (P ＜ 0.05).The liver function damage in treatment group was lower than that in control group (P ＜ 0.05).The cellular immune function in treatment group was stronger than that in control group (P ＜ 0.05).Conclusion Ozone therapy combined with GP regimen can effectively alleviate adverse induced by GP regimen chemotherapy and significantly improve the quality of life in patients with advanced non-small cell lung cancer.