中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
34期
42-44
,共3页
肺疾病,慢性阻塞性%呼吸功能不全%预后因素
肺疾病,慢性阻塞性%呼吸功能不全%預後因素
폐질병,만성조새성%호흡공능불전%예후인소
Pulmonary disease,chronic obstructive%Respiratory insufficiency%Prognosis
目的 探讨影响慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭预后的危险因素.方法 回顾性分析120例AECOPD合并呼吸衰竭患者,根据其治疗结果分为病情好转组(96例)和病情加重(包括死亡)组(24例),分析其临床资料及治疗措施等因素.结果 两组年龄、性别构成、病程、动脉血氧分压比较差异无统计学意义(P>0.05).病情好转组体质量指数、白蛋白、pH值、咳嗽咳痰能力良好率、营养支持率、无创机械通气率高于病情加重组[(28.5±9.8) kg/m2比(23.3±7.4)kg/m2、(21.4±7.9)g/L比(19.3±6.8)g/L、7.23±0.20比7.11 ±0.17、79.2% (76/96)比25.0%(6/24)、58.3%(56/96)比33.3%(8/24)、81.2%(78/96)比62.5%(15/24)],动脉血二氧化碳分压、轻度神志障碍率、多重耐药感染率、真菌感染率、鼻饲率、激素使用时间及心力衰竭、肺性脑病、肝肾功能损害、上消化道出血发生率均低于病情加重组[(10.08±1.71) kPa比(11.98±2.03) kPa、13.5%(13/96)比58.3%(14/24)、22.9%(22/96)比41.7%(10/24)、0比29.2%(7/24)、50.0%(48/96)比75.0%(18/24)、(5.3±1.3)d比(11.3±3.8)d、8.3%(8/96)比25.0%(6/24)、13.5%(13/96)比70.8%(17/24)、28.1%(27/96)比41.7%(10/24)、5.2%(5/96)比12.5%(3/24)],差异有统计学意义(P<0.05).结论 在AECOPD合并呼吸衰竭患者中,并发症、营养状况、神志、咳嗽咳痰能力、感染情况、有效的无创正压通气、血气指标等可作为影响其预后的相关因素.
目的 探討影響慢性阻塞性肺疾病急性加重期(AECOPD)閤併呼吸衰竭預後的危險因素.方法 迴顧性分析120例AECOPD閤併呼吸衰竭患者,根據其治療結果分為病情好轉組(96例)和病情加重(包括死亡)組(24例),分析其臨床資料及治療措施等因素.結果 兩組年齡、性彆構成、病程、動脈血氧分壓比較差異無統計學意義(P>0.05).病情好轉組體質量指數、白蛋白、pH值、咳嗽咳痰能力良好率、營養支持率、無創機械通氣率高于病情加重組[(28.5±9.8) kg/m2比(23.3±7.4)kg/m2、(21.4±7.9)g/L比(19.3±6.8)g/L、7.23±0.20比7.11 ±0.17、79.2% (76/96)比25.0%(6/24)、58.3%(56/96)比33.3%(8/24)、81.2%(78/96)比62.5%(15/24)],動脈血二氧化碳分壓、輕度神誌障礙率、多重耐藥感染率、真菌感染率、鼻飼率、激素使用時間及心力衰竭、肺性腦病、肝腎功能損害、上消化道齣血髮生率均低于病情加重組[(10.08±1.71) kPa比(11.98±2.03) kPa、13.5%(13/96)比58.3%(14/24)、22.9%(22/96)比41.7%(10/24)、0比29.2%(7/24)、50.0%(48/96)比75.0%(18/24)、(5.3±1.3)d比(11.3±3.8)d、8.3%(8/96)比25.0%(6/24)、13.5%(13/96)比70.8%(17/24)、28.1%(27/96)比41.7%(10/24)、5.2%(5/96)比12.5%(3/24)],差異有統計學意義(P<0.05).結論 在AECOPD閤併呼吸衰竭患者中,併髮癥、營養狀況、神誌、咳嗽咳痰能力、感染情況、有效的無創正壓通氣、血氣指標等可作為影響其預後的相關因素.
목적 탐토영향만성조새성폐질병급성가중기(AECOPD)합병호흡쇠갈예후적위험인소.방법 회고성분석120례AECOPD합병호흡쇠갈환자,근거기치료결과분위병정호전조(96례)화병정가중(포괄사망)조(24례),분석기림상자료급치료조시등인소.결과 량조년령、성별구성、병정、동맥혈양분압비교차이무통계학의의(P>0.05).병정호전조체질량지수、백단백、pH치、해수해담능력량호솔、영양지지솔、무창궤계통기솔고우병정가중조[(28.5±9.8) kg/m2비(23.3±7.4)kg/m2、(21.4±7.9)g/L비(19.3±6.8)g/L、7.23±0.20비7.11 ±0.17、79.2% (76/96)비25.0%(6/24)、58.3%(56/96)비33.3%(8/24)、81.2%(78/96)비62.5%(15/24)],동맥혈이양화탄분압、경도신지장애솔、다중내약감염솔、진균감염솔、비사솔、격소사용시간급심력쇠갈、폐성뇌병、간신공능손해、상소화도출혈발생솔균저우병정가중조[(10.08±1.71) kPa비(11.98±2.03) kPa、13.5%(13/96)비58.3%(14/24)、22.9%(22/96)비41.7%(10/24)、0비29.2%(7/24)、50.0%(48/96)비75.0%(18/24)、(5.3±1.3)d비(11.3±3.8)d、8.3%(8/96)비25.0%(6/24)、13.5%(13/96)비70.8%(17/24)、28.1%(27/96)비41.7%(10/24)、5.2%(5/96)비12.5%(3/24)],차이유통계학의의(P<0.05).결론 재AECOPD합병호흡쇠갈환자중,병발증、영양상황、신지、해수해담능력、감염정황、유효적무창정압통기、혈기지표등가작위영향기예후적상관인소.
Objective To investigate the risk factors of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) combined with respiratory failure.Methods The clinical data of 120 patients with AECOPD combined with respiratory failure were retrospectively analyzed.The patients were divided into disease improved group (96 cases) and disease serious group (24 cases,including death) according to the treatment outcome.Risk factor and treatment strategies of the two groups were statistically analyzed.Results There was no significant difference in age,sex,disease course and arterial blood oxygen partial pressure(P > 0.05).The body mass index,albumin,pH,successful cough and expectoration rate,nutritional support rate,and noninvasive mechanical ventilation rate in disease improved group was higher than that in disease serious group[(28.5 ± 9.8) kg/m2 vs.(23.3 ± 7.4) kg/m2,(21.4 ± 7.9) g/L vs.(19.3 ± 6.8) g/L,7.23 ± 0.20 vs.7.11 ± 0.17,79.2% (76/96) vs.25.0% (6/24),58.3% (56/96) vs.33.3% (8/24),81.2% (78/96) vs.62.5% (15/24)],arterial blood carbon dioxide partial pressure,mild consciousness obstacle rate,multiple drug-resistant infections rate,fungal infection rate,nasal feeding rate,hormone use time and the incidence of heart failure,pulmonary encephalopathy,hepatorenal function damage and upper gastrointestinal bleeding in disease improved group was lower than that in disease serious group [(10.08 ±1.71) kPa vs.(11.98 ± 2.03) kPa,13.5% (13/96) vs.58.3% (14/24),22.9% (22/96) vs.41.7% (10/24),0 vs.29.2% (7/24),50.0%(48/96) vs.75.0%(18/24),(5.3 ± 1.3) d vs.(11.3 ± 3.8) d,8.3%(8/96) vs.25.0%(6/24),13.5%(13/96) vs.70.8%(17/24),28.1%(27/96) vs.41.7%(10/24),5.2%(5/96) vs.12.5%(3/24)],and there was significant difference (P < 0.05).Conclusion Complicating disease,nutritional status,consciousness,capability of sputum exclusion,the degree of respiratory infection,treatment with noninv asive positive pressure ventilation,arterial gas analysis index are the correlated factors of prognosis in AECOPD combined with respiratory failure.