CAJ | 학술논문

目的考察右美托咪定在未建立人工气道的颅脑疾病患者支气管肺泡灌洗过程中的作用.方法对46例颅脑疾病后无人工气道的肺部感染患者行支气管肺泡灌洗治疗,年龄17～82岁,平均年龄(56.6±9.2)岁,其中男性26例,女性20例.随机分为2组,其中对照组23例,支气管肺泡灌洗过程中接受咪达唑仑镇静;实验组23例,支气管肺泡灌洗过程中接受右美托咪定镇静.观察2组患者在支气管肺泡灌洗前和灌洗过程中的心率、平均动脉压及指脉氧等指标的变化.结果支气管肺泡灌洗过程中最低指脉氧实验组高于对照组,最快心率实验组低于对照组,最低平均动脉压实验组高于对照组,差异均具有统计学意义(P＜0.05).支气管肺泡灌洗过程中与灌洗前比较,2组心率均有增快,平均动脉压下降,指脉氧下降,但实验组各指标的幅度变化较小(P＜0.05).结论右美托咪定对患者呼吸和血压抑制较小,用于无人工气道的颅脑疾病患者的支气管肺泡灌洗过程相对安全有效.
목적 고찰우미탁미정재미건립인공기도적로뇌질병환자지기관폐포관세과정중적작용.방법 대46례로뇌질병후무인공기도적폐부감염환자행지기관폐포관세치료,년령17～82세,평균년령(56.6±9.2)세,기중남성26례,녀성20례.수궤분위2조,기중대조조23례,지기관폐포관세과정중접수미체서륜진정;실험조23례,지기관폐포관세과정중접수우미탁미정진정.관찰2조환자재지기관폐포관세전화관세과정중적심솔、평균동맥압급지맥양등지표적변화.결과 지기관폐포관세과정중최저지맥양실험조고우대조조,최쾌심솔실험조저우대조조,최저평균동맥압실험조고우대조조,차이균구유통계학의의(P＜0.05).지기관폐포관세과정중여관세전비교,2조심솔균유증쾌,평균동맥압하강,지맥양하강,단실험조각지표적폭도변화교소(P＜0.05).결론 우미탁미정대환자호흡화혈압억제교소,용우무인공기도적로뇌질병환자적지기관폐포관세과정상대안전유효.
Objective To analyze the effect of dexmedetomidine hydrochloride injection on patients with craniocerebral disease who has no artificial airway in the process of bronchoalveolar lavage treatment.Methods Forty-six patients (age 17-28,average age 56.6±9.2,26 men and 20 women) with craniocerebral disease who has no artificial airway were selected,and were treated by bronchoalveolar lavage for lung infection.The patients were randomly divided into two groups,control and test group.The control group (n=23) received midazolam for sedative and the test group (n=23) received dexmedetomidine hydrochloride for sedative while they were in the process of bronchoalveolar lavage treatment.Heart rate,mean arterial pressure and blood oxygen saturation of fingers collected from patients before and during the process of bronchoalveolar lavage were compared.Results In the process of bronchoalveolar lavage treatment,the minimum blood oxygen saturation of finger artery from the control group was lower than that from the test group,the fastest heart rate from the control group was greater than that from the test group,and the lowest mean arterial pressure from the control group was lower than that from the test group (P＜0.05).In two groups,heart rate in the process of bronchoalveolar lavage treatment was faster than that from before the treatment,while both mean arterial pressure and blood oxygen saturation of finger artery were decreased (P＜0.05).Conclusions Continuous intravenous pumping of dexmedetomidine hydrochloride on patients with craniocerebral disease who has no artificial airway during the process of bronchoalveolar lavage treatment is effective and safe,and it has less inhibitory effect on respiratory function and blood pressure.