CAJ | 학술논문

自主神经系统包括交感神经系统及副交感神经(迷走神经)系统,其对维持人体稳态极为重要.自主神经功能紊乱可引起许多疾病,如直立不耐受等.近年关于维生素D与心血管疾病的关联性研究已逐渐引起重视.1,25-(OH)2D参与肾素-血管紧张素系统的调节,发挥血管效应,其不足时可导致继发性甲状旁腺功能亢进、高血压、糖尿病、血脂异常,进一步影响心血管疾患的发生及预后.研究证实维生素D不足容易出现心脏自主神经功能紊乱,是直立性低血压等自主神经功能紊乱疾病的危险因素之一,但机制尚不完全明确.补充维生素D可降低维生素D缺乏人群的心血管疾病风险.
자주신경계통포괄교감신경계통급부교감신경(미주신경)계통,기대유지인체은태겁위중요.자주신경공능문란가인기허다질병,여직립불내수등.근년관우유생소D여심혈관질병적관련성연구이축점인기중시.1,25-(OH)2D삼여신소-혈관긴장소계통적조절,발휘혈관효응,기불족시가도치계발성갑상방선공능항진、고혈압、당뇨병、혈지이상,진일보영향심혈관질환적발생급예후.연구증실유생소D불족용역출현심장자주신경공능문란,시직립성저혈압등자주신경공능문란질병적위험인소지일,단궤제상불완전명학.보충유생소D가강저유생소D결핍인군적심혈관질병풍험.
The automatic nervous system(ANS) has 2 main branches:the sympathetic nervous system and the parasympathetic nervous system.The ANS controls mainly automatic bodily functions that are engaged in homeostasis.Autonomic dysfunction lead to many diseases,for example,orthostatic intolerance etc.The relationship between vitamin D and cardiovascular disease has becomes the focus of study gradually in recent years.1,25-dihydroxy vitamin D participates in the regulation of renin-angiotensin axis,vascular effects.Vitamin D deficiency triggers secondary hyperparathyroidism,promotes the development of hypertension,diabetes,dyslipidemia which can influence the incidence and prognosis of cardiovascular disease as well.The study confirmed that vitamin D deficiency is one of the risk factors of cardiac autonomic dysfunction diseases such as orthostatic intolerance.The mechanism is still not very clear.Supplement of vitamin D can offer an effective method to decrease cardiovascular disease risk in populations with low vitamin D status.