CAJ | 학술논문

钙激活性氯通道(CaCCs)在心血管系统发挥重要作用,参与多种生理功能,并且与多种疾病的病理过程有关.随着研究的深入,近来发现CaCCs的重要分子基础为跨膜蛋白16a(TMEM16A),且该蛋白在心血管系统中发挥重要作用.现综述TMEM16A在心血管系统研究中的主要进展和关键问题,讨论TMEM16A在心血管系统的表达、生理功能以及与某些心血管疾病的临床病理联系等问题,并在此基础上,对TMEM16A在心血管疾病的靶向治疗的研究前景方面进行展望.
개격활성록통도(CaCCs)재심혈관계통발휘중요작용,삼여다충생리공능,병차여다충질병적병리과정유관.수착연구적심입,근래발현CaCCs적중요분자기출위과막단백16a(TMEM16A),차해단백재심혈관계통중발휘중요작용.현종술TMEM16A재심혈관계통연구중적주요진전화관건문제,토론TMEM16A재심혈관계통적표체、생리공능이급여모사심혈관질병적림상병리련계등문제,병재차기출상,대TMEM16A재심혈관질병적파향치료적연구전경방면진행전망.
Calcium-activated chloride channels(CaCCs) play an important role in cardiovascular system,including participating in a variety of physiological functions and being associated with the pathology progress of many cardiovascular diseases.With the development of research,transmembrane protein 16a (TMEM16A) has recently been identified as the molecular basis of CaCCs.Since the study of TMEM16A has got some achievement,especially in the section of cardiovascular system,its main research progress and key points from previous researches are summarized,in which the expression and physiological function of TMEM16A,as well as its clinical pathological correlations with some cardiovascular diseases are told about.Besides,the research prospect of TMEM16A in targeting therapy of cardiovascular disease is also discussed.