中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2014年
23期
1801-1805
,共5页
龚辉%陈香梅%郭郑旻%黄付敏%熊艳蕾%徐涛%韩少梅%徐成丽
龔輝%陳香梅%郭鄭旻%黃付敏%熊豔蕾%徐濤%韓少梅%徐成麗
공휘%진향매%곽정민%황부민%웅염뢰%서도%한소매%서성려
儿童%青少年%丙氨酸氨基转移酶%天门冬氨酸氨基转移酶%γ-谷氨酰转移酶
兒童%青少年%丙氨痠氨基轉移酶%天門鼕氨痠氨基轉移酶%γ-穀氨酰轉移酶
인동%청소년%병안산안기전이매%천문동안산안기전이매%γ-곡안선전이매
Child%Adolescent%Alanine aminotransferase%Aspartate aminotransferase%Gamma glutamine transferase
目的 探讨黑龙江省儿童青少年年龄、性别、体质表型维度[体质量指数(BMI)、腰围(WC)、腰围身高比(WhtR)]与血清肝酶水平的关系,为儿童青少年早期健康干预提供科学依据.方法 分层整群随机抽取黑龙江省部分地区2008年7月至10月10～18岁健康儿童青少年2 011人(男902人,女1 109人;汉族1 177人,朝鲜族834人),测量身高、体质量和WC,速率法检测血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)及γ-谷氨酰转移酶(GGT)活性,用Pearson相关分析和多元逐步回归等统计学方法分析年龄、民族、BMI、WC、WhtR与血清肝酶水平的关系.结果 不同性别受试者的年龄与其血清LgALT(男r=0.100,P＜0.05;女r=0.086,P＜0.05)和LgGGT(男r=0.262,P＜0.05;女r=0.072,P＜0.05)水平呈正相关,与其血清LgAST(男r=-0.201,P＜0.001;女r=-0.227,P＜0.001)水平呈负相关.血清LgALT、LgAST及LgGGT水平在11 ～18岁儿童青少年中均存在性别差异,同年龄段男性均高于女性(P＜0.05).朝鲜族男性和女性儿童青少年血清LgALT水平均高于同性别汉族儿童青少年(P＜0.001).超重组和肥胖组男性和女性儿童青少年血清LgALT和LgGGT水高于同性别BMI正常组(P＜0.01),肥胖组男性儿童青少年血清LgALT、LgAST及LgGGT水平均明显高于同性别超重组(P＜0.05).多元逐步回归分析显示,男性儿童青少年血清LgALT水平主要受年龄、民族、WhtR影响,LgAST仅受年龄影响,LgGGT主要受年龄、BMI和WhtR影响;女性儿童青少年血清LgALT水平主要受民族和WhtR影响,LgAST主要受年龄、WC和WhtR影响,LgGGT仅受BMI影响.结论 儿童青少年血清肝酶水平与年龄、性别、体质表型维度及民族均有相关性,故要重视超重或肥胖儿童青少年血清肝酶水平的监测,制定科学的饮食和运动等干预措施,以减少肝脏内脂肪的堆积.
目的 探討黑龍江省兒童青少年年齡、性彆、體質錶型維度[體質量指數(BMI)、腰圍(WC)、腰圍身高比(WhtR)]與血清肝酶水平的關繫,為兒童青少年早期健康榦預提供科學依據.方法 分層整群隨機抽取黑龍江省部分地區2008年7月至10月10～18歲健康兒童青少年2 011人(男902人,女1 109人;漢族1 177人,朝鮮族834人),測量身高、體質量和WC,速率法檢測血清丙氨痠氨基轉移酶(ALT)、天門鼕氨痠氨基轉移酶(AST)及γ-穀氨酰轉移酶(GGT)活性,用Pearson相關分析和多元逐步迴歸等統計學方法分析年齡、民族、BMI、WC、WhtR與血清肝酶水平的關繫.結果 不同性彆受試者的年齡與其血清LgALT(男r=0.100,P＜0.05;女r=0.086,P＜0.05)和LgGGT(男r=0.262,P＜0.05;女r=0.072,P＜0.05)水平呈正相關,與其血清LgAST(男r=-0.201,P＜0.001;女r=-0.227,P＜0.001)水平呈負相關.血清LgALT、LgAST及LgGGT水平在11 ～18歲兒童青少年中均存在性彆差異,同年齡段男性均高于女性(P＜0.05).朝鮮族男性和女性兒童青少年血清LgALT水平均高于同性彆漢族兒童青少年(P＜0.001).超重組和肥胖組男性和女性兒童青少年血清LgALT和LgGGT水高于同性彆BMI正常組(P＜0.01),肥胖組男性兒童青少年血清LgALT、LgAST及LgGGT水平均明顯高于同性彆超重組(P＜0.05).多元逐步迴歸分析顯示,男性兒童青少年血清LgALT水平主要受年齡、民族、WhtR影響,LgAST僅受年齡影響,LgGGT主要受年齡、BMI和WhtR影響;女性兒童青少年血清LgALT水平主要受民族和WhtR影響,LgAST主要受年齡、WC和WhtR影響,LgGGT僅受BMI影響.結論 兒童青少年血清肝酶水平與年齡、性彆、體質錶型維度及民族均有相關性,故要重視超重或肥胖兒童青少年血清肝酶水平的鑑測,製定科學的飲食和運動等榦預措施,以減少肝髒內脂肪的堆積.
목적 탐토흑룡강성인동청소년년령、성별、체질표형유도[체질량지수(BMI)、요위(WC)、요위신고비(WhtR)]여혈청간매수평적관계,위인동청소년조기건강간예제공과학의거.방법 분층정군수궤추취흑룡강성부분지구2008년7월지10월10～18세건강인동청소년2 011인(남902인,녀1 109인;한족1 177인,조선족834인),측량신고、체질량화WC,속솔법검측혈청병안산안기전이매(ALT)、천문동안산안기전이매(AST)급γ-곡안선전이매(GGT)활성,용Pearson상관분석화다원축보회귀등통계학방법분석년령、민족、BMI、WC、WhtR여혈청간매수평적관계.결과 불동성별수시자적년령여기혈청LgALT(남r=0.100,P＜0.05;녀r=0.086,P＜0.05)화LgGGT(남r=0.262,P＜0.05;녀r=0.072,P＜0.05)수평정정상관,여기혈청LgAST(남r=-0.201,P＜0.001;녀r=-0.227,P＜0.001)수평정부상관.혈청LgALT、LgAST급LgGGT수평재11 ～18세인동청소년중균존재성별차이,동년령단남성균고우녀성(P＜0.05).조선족남성화녀성인동청소년혈청LgALT수평균고우동성별한족인동청소년(P＜0.001).초중조화비반조남성화녀성인동청소년혈청LgALT화LgGGT수고우동성별BMI정상조(P＜0.01),비반조남성인동청소년혈청LgALT、LgAST급LgGGT수평균명현고우동성별초중조(P＜0.05).다원축보회귀분석현시,남성인동청소년혈청LgALT수평주요수년령、민족、WhtR영향,LgAST부수년령영향,LgGGT주요수년령、BMI화WhtR영향;녀성인동청소년혈청LgALT수평주요수민족화WhtR영향,LgAST주요수년령、WC화WhtR영향,LgGGT부수BMI영향.결론 인동청소년혈청간매수평여년령、성별、체질표형유도급민족균유상관성,고요중시초중혹비반인동청소년혈청간매수평적감측,제정과학적음식화운동등간예조시,이감소간장내지방적퇴적.
Objective To investigate the associations of age,gender and physical phenotypic dimensions,such as body mass index (BMI),waist circumference (WC),waist-to-height ratio (WhtR),with serum liver enzyme levels among children and adolescents of Heilongjiang province,and to provide scientific evidence for early health prevention and treatment among children and adolescents.Methods The overall samples were collected by multistage stratified random cluster sampling method from Jul.to Oct.in 2008 in Heilongjiang province.Height,weight and WC were measured,and the se-rum alanine aminotransferase(ALT),aspartate aminotransferase(AST) and gamma glutamine transferase(GGT) levels were detected by using rate assay among 2 011 enrolled children and adolescents(902 males and 1 109 females;Han 1 177 cases,and Korean 834 cases) aged 10-18 years with complete data.The associations of BMI,WC and WhtR with serum liver enzyme levels were analyzed by Pearson linear correlation and multiple stepwise regression analysis.Results Among 10-18 years old children and adolescents of different gender,the serum LgALT (male r =0.100,P ＜ 0.05 ; female r =0.086,P ＜ 0.05) and LgGGT (male r =0.262,P ＜ 0.05 ; female r =0.072,P ＜ 0.05)were positively correlated with age,while serum LgAST(male r =-0.201,P ＜ 0.001 ;female r =-0.227,P ＜ 0.001)levels were negatively correlated with age.The gender difference in serum LgALT,LgAST and LgGGT existed for each age group among 11-18 years old children and adolescents,with male higher than female.In addition,the serum LgALT level in the Korean children and adolescents were higher than that in both sexes of Han nationality.The serum LgALT and LgGGT levels in overweight and obese children and adolescents were significantly higher than that in BMI normal group with the same gender for both sexes (P ＜ 0.01),and serum LgALT,LgAST and LgGGT levels in male obese children and adolescents were significantly higher than that in overweight group with the same gender (P ＜ 0.05).By the multiple regression analysis,among male children and adolescents,serum LgALT level was mainly effected by age,nationa-lity and WhtR,serum LgAST level was mainly effected by age,and serum LgGGT level was mainly influenced by age,BMI and WhtR; among female children and adolescents,serum LgALT level was mainly affected by nationality and WhtR,serum LgAST level was mainly influenced by age,WC and WhtR,and serum LgGGT level was mainly influenced by BMI.Conclusions There exist certain associations among age,gender,physical phenotypic dimension and nationa-lity with serum liver enzyme levels among children and adolescents,so more attention should be paid to monitor the serum liver enzyme levels among the overweight and obese children and adolescents.And scientific diet and more exercise are suggested so as to reduce the liver fat.
