CAJ | 학술논문

程序性凋亡分子-1(PD-1)及其配体(PD-L1)是抑制性共同刺激分子中的重要成员之一,在多种肿瘤细胞及其相关细胞表面高表达,而肿瘤浸润的T淋巴细胞中调节性T淋巴细胞(Treg)的比例也异常升高.PD-L1与PD-1结合和Treg帮助肿瘤逃避免疫清除减弱了免疫应答和诱导免疫耐受.最新研究发现,PD-L1分子是诱导型Treg(iTreg)发育和功能维持的重要分子,PD-L1信号可将初始CD4+ CD25-T细胞转化成iTreg,发挥免疫抑制作用.对PD-1信号通道的研究可为抑制肿瘤免疫逃逸临床应用中肿瘤的免疫治疗提供新的理论依据和更好的治疗方法.
정서성조망분자-1(PD-1)급기배체(PD-L1)시억제성공동자격분자중적중요성원지일,재다충종류세포급기상관세포표면고표체,이종류침윤적T림파세포중조절성T림파세포(Treg)적비례야이상승고.PD-L1여PD-1결합화Treg방조종류도피면역청제감약료면역응답화유도면역내수.최신연구발현,PD-L1분자시유도형Treg(iTreg)발육화공능유지적중요분자,PD-L1신호가장초시CD4+ CD25-T세포전화성iTreg,발휘면역억제작용.대PD-1신호통도적연구가위억제종류면역도일림상응용중종류적면역치료제공신적이론의거화경호적치료방법.
Programmed death-1 (PD-1) and its ligand PD-L1 are the major members of inhibitory costimulatory molecules and express high in a variety of tumor cells and their associated cells surface,while the proportion of regulatory T cells (Tregs) are abnormally elevated in tumor infiltrating T lymphocytes cells.PD-L1 combined with PD-1 and Treg help tumors evade immune clearance,weaken immune responses and induce immune tolerance.New researches find that PD-L1 plays an important role in the development and function maintenance of inducible Treg (iTreg),and PD-L1 signal can change initial CD4 + CD25-T cells into iTreg to play a role of immunosuppression.Research on PD-1 signaling pathway can provide a new theoretical basis for the inhibition of tumor immune escape in clinical application of immunotherapy and better treatments.