国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
11期
811-812
,共2页
游颜杰%李文梅%刘佳佳%苑艺
遊顏傑%李文梅%劉佳佳%苑藝
유안걸%리문매%류가가%원예
基因,肿瘤抑制%肿瘤%肿瘤标记,生物学%诊断
基因,腫瘤抑製%腫瘤%腫瘤標記,生物學%診斷
기인,종류억제%종류%종류표기,생물학%진단
Genes,tumor suppressor%Neoplasms%Tumor markers,biological%Diagnosis
周期素依赖性激酶10(CDK10)通过与转录因子Ets2相互作用参与调控细胞周期,发挥抑癌基因的作用.研究表明CDK10表达下调与多种肿瘤形成密切相关,提示CDK10有希望成为针对恶性肿瘤的潜在分子诊断标志物和治疗靶点.
週期素依賴性激酶10(CDK10)通過與轉錄因子Ets2相互作用參與調控細胞週期,髮揮抑癌基因的作用.研究錶明CDK10錶達下調與多種腫瘤形成密切相關,提示CDK10有希望成為針對噁性腫瘤的潛在分子診斷標誌物和治療靶點.
주기소의뢰성격매10(CDK10)통과여전록인자Ets2상호작용삼여조공세포주기,발휘억암기인적작용.연구표명CDK10표체하조여다충종류형성밀절상관,제시CDK10유희망성위침대악성종류적잠재분자진단표지물화치료파점.
Cyclin-dependent kinase 10 (CDK10) function as a tumor suppressor gene through regulating cell cycle interacting with transcription factor Ets2.Studies demonstrate that the downregulation of CDK10 expression occurs in multiple cancer types,indicating a potential application of CDK10 as a molecular diagnostic marker as well as therapeutic target.
