国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2014年
6期
28-30
,共3页
王福诩%苏小芳%卢冠解%黄芝%龙健中
王福詡%囌小芳%盧冠解%黃芝%龍健中
왕복후%소소방%로관해%황지%룡건중
血液灌流%血液透析%尿毒症周围神经病变
血液灌流%血液透析%尿毒癥週圍神經病變
혈액관류%혈액투석%뇨독증주위신경병변
Hemoperfusion%Hemodialysis%Uremic peripheral neuropathy
目的 探讨血液灌流联合血液透析对尿毒症周围神经病变的疗效和机制.方法 将54例尿毒症周围神经病变的血液透析患者按数字表法随机分为血液灌流+血液透析组(HD+HP)和常规血液透析组(HD).HD+ HP组行每周连续3次HD+ HP治疗;常规血液透析组(HD)行每周3次常规HD治疗.治疗4周,比较治疗前后两组患者周围神经病变的临床症状、血PTH、β2-MG浓度和正中神经、胫神经、腓总神经的感觉神经传导速度(SCV)变化,分析PTH和β2-MG与SCV的相关性.结果 经过4周的治疗后,HD组患者周围神经病变的临床症状、血PTH、β2-MG、感觉神经传导速度无明显改善,而HD+HP组患者周围神经病变的临床症状、血PTH、β2-MG及SCV均较治疗前有明显改善,其程度显著优于HD组(P＜0.05),PTH和β2-MG与SCV有明显的相关性(P＜0.05).结论 连续短期HD+ HP能有效清除PTH和β2-MG,且对治疗尿毒症周围神经病变有效;PTH和β2-MG在体内蓄积与尿毒症周围神经病变有关.
目的 探討血液灌流聯閤血液透析對尿毒癥週圍神經病變的療效和機製.方法 將54例尿毒癥週圍神經病變的血液透析患者按數字錶法隨機分為血液灌流+血液透析組(HD+HP)和常規血液透析組(HD).HD+ HP組行每週連續3次HD+ HP治療;常規血液透析組(HD)行每週3次常規HD治療.治療4週,比較治療前後兩組患者週圍神經病變的臨床癥狀、血PTH、β2-MG濃度和正中神經、脛神經、腓總神經的感覺神經傳導速度(SCV)變化,分析PTH和β2-MG與SCV的相關性.結果 經過4週的治療後,HD組患者週圍神經病變的臨床癥狀、血PTH、β2-MG、感覺神經傳導速度無明顯改善,而HD+HP組患者週圍神經病變的臨床癥狀、血PTH、β2-MG及SCV均較治療前有明顯改善,其程度顯著優于HD組(P＜0.05),PTH和β2-MG與SCV有明顯的相關性(P＜0.05).結論 連續短期HD+ HP能有效清除PTH和β2-MG,且對治療尿毒癥週圍神經病變有效;PTH和β2-MG在體內蓄積與尿毒癥週圍神經病變有關.
목적 탐토혈액관류연합혈액투석대뇨독증주위신경병변적료효화궤제.방법 장54례뇨독증주위신경병변적혈액투석환자안수자표법수궤분위혈액관류+혈액투석조(HD+HP)화상규혈액투석조(HD).HD+ HP조행매주련속3차HD+ HP치료;상규혈액투석조(HD)행매주3차상규HD치료.치료4주,비교치료전후량조환자주위신경병변적림상증상、혈PTH、β2-MG농도화정중신경、경신경、비총신경적감각신경전도속도(SCV)변화,분석PTH화β2-MG여SCV적상관성.결과 경과4주적치료후,HD조환자주위신경병변적림상증상、혈PTH、β2-MG、감각신경전도속도무명현개선,이HD+HP조환자주위신경병변적림상증상、혈PTH、β2-MG급SCV균교치료전유명현개선,기정도현저우우HD조(P＜0.05),PTH화β2-MG여SCV유명현적상관성(P＜0.05).결론 련속단기HD+ HP능유효청제PTH화β2-MG,차대치료뇨독증주위신경병변유효;PTH화β2-MG재체내축적여뇨독증주위신경병변유관.
Objective To explore the efficacy and mechanism of hemodialysis+ hemoperfusion(HD + HP)in treating uremic peripheral neuropathy.Methods 54 uremic peripheral neuropathy patients were randomly divided into two groups:HD + Hp group and conventional hemodialysis group (HD).HD + HP group consecutively received HD + HP treatment 3 times per week; HD group received HD treatment 3 times per week.Based on 4 weeks' observation and treatment,we compared two groups' clinical symptom,blood PTH,β2-MG concentration and the SCV change of median nerve,tibial nerve,peroneal nerve and analyzed the correlation between PTH and β2-MG and SCV.Results After 4 weeks' treatment,there were no obvious improvement in peripheral neuropathy clinical symptom,blood PTH,β2-MG concentration and the SCV of HD group,but HD + HP group's neuropathy clinical symptom,blood PTH,β2-MG concentration and the SCV had improved significantly,which was substantially better than HD group(P ＜ 0.05).There was obvious correlation between PTH,β2-MG and SCV(P ＜ 0.05).Conclusions Continuous short-term HD+ Hp can effectively remove PTH and β2-MG and treat peripheral neuropathy; PTH and β2-MG accumulation in patients' body is related with uremic peripheral neuropathy.
