国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2014年
6期
38-41
,共4页
On-line血液透析滤过%血液透析%血钙%血磷%全段甲状旁腺激素%碱性磷酸酶
On-line血液透析濾過%血液透析%血鈣%血燐%全段甲狀徬腺激素%堿性燐痠酶
On-line혈액투석려과%혈액투석%혈개%혈린%전단갑상방선격소%감성린산매
On-line hemodiafihration%Hemodialysis%Serum calcium%Serum phosphorus%Intact parathyroid hormone%Alkaline phosphatase
目的 探讨On-line血液透析滤过技术对维持性血液透析患者矿物质代谢的影响.方法 选取尿毒症维持性血液透析患者110例,采用数字表法随机分为常规血液透析治疗组(HD组)和On-line血液透析滤过治疗组(HDF组),每组各55例.HD组患者每周行3次血液透析治疗,HDF组患者每周行2次常规血液透析治疗,1次血液透析滤过,时间均为4h.监测治疗当天和治疗3个月后患者外周血中血清钙离子、磷、全段甲状旁腺激素(iPTH)及碱性磷酸酶(ALP)等矿物质代谢的评估指标.结果 治疗前两组患者血钙、磷、iPTH及ALP水平差异无统计学意义(均P＞0.05).治疗3个月后,HD组血钙、iPTH和ALP与治疗前比较差异无统计学意义(均P＞0.05),血磷低于治疗前水平,与治疗前比较差异有统计学意义(P＜0.05).HDP组治疗后血磷、iPTH和ALP较治疗前下降明显(均P＜0.01).治疗后,HDF组血磷和ALP较HD组显著降低,差异有统计学意义(P＜0.05),iPTH降低更为显著(P＜0.01).结论 与普通血液透析比较,On-line血液透析滤过治疗能有效清除血磷,降低iPTH和ALP水平,从而改善维持性血液透析患者的矿物质代谢异常.
目的 探討On-line血液透析濾過技術對維持性血液透析患者礦物質代謝的影響.方法 選取尿毒癥維持性血液透析患者110例,採用數字錶法隨機分為常規血液透析治療組(HD組)和On-line血液透析濾過治療組(HDF組),每組各55例.HD組患者每週行3次血液透析治療,HDF組患者每週行2次常規血液透析治療,1次血液透析濾過,時間均為4h.鑑測治療噹天和治療3箇月後患者外週血中血清鈣離子、燐、全段甲狀徬腺激素(iPTH)及堿性燐痠酶(ALP)等礦物質代謝的評估指標.結果 治療前兩組患者血鈣、燐、iPTH及ALP水平差異無統計學意義(均P＞0.05).治療3箇月後,HD組血鈣、iPTH和ALP與治療前比較差異無統計學意義(均P＞0.05),血燐低于治療前水平,與治療前比較差異有統計學意義(P＜0.05).HDP組治療後血燐、iPTH和ALP較治療前下降明顯(均P＜0.01).治療後,HDF組血燐和ALP較HD組顯著降低,差異有統計學意義(P＜0.05),iPTH降低更為顯著(P＜0.01).結論 與普通血液透析比較,On-line血液透析濾過治療能有效清除血燐,降低iPTH和ALP水平,從而改善維持性血液透析患者的礦物質代謝異常.
목적 탐토On-line혈액투석려과기술대유지성혈액투석환자광물질대사적영향.방법 선취뇨독증유지성혈액투석환자110례,채용수자표법수궤분위상규혈액투석치료조(HD조)화On-line혈액투석려과치료조(HDF조),매조각55례.HD조환자매주행3차혈액투석치료,HDF조환자매주행2차상규혈액투석치료,1차혈액투석려과,시간균위4h.감측치료당천화치료3개월후환자외주혈중혈청개리자、린、전단갑상방선격소(iPTH)급감성린산매(ALP)등광물질대사적평고지표.결과 치료전량조환자혈개、린、iPTH급ALP수평차이무통계학의의(균P＞0.05).치료3개월후,HD조혈개、iPTH화ALP여치료전비교차이무통계학의의(균P＞0.05),혈린저우치료전수평,여치료전비교차이유통계학의의(P＜0.05).HDP조치료후혈린、iPTH화ALP교치료전하강명현(균P＜0.01).치료후,HDF조혈린화ALP교HD조현저강저,차이유통계학의의(P＜0.05),iPTH강저경위현저(P＜0.01).결론 여보통혈액투석비교,On-line혈액투석려과치료능유효청제혈린,강저iPTH화ALP수평,종이개선유지성혈액투석환자적광물질대사이상.
Objective To investigate the effects of On-line hemodiafiltration on mineral metabolism of maintenance hemodialysis(MHD) patients with uremia.Methods A total of 110 patients with uremia and MHD were randomly assigned to two groups.The patients in the hemodialysis (HD) group received routine HD 3 times per week,and the patients in the HDF group received one on-line HDF and 2 routine HD treatment.The evaluation index of all the patients were collected right before HD and 3 months after the treatment,including serum calcium,serum phosphorus,intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP).Results There were no statistical difference of the serum levels of calcium,phosphorus,iPTH and ALP in two groups before the treatment(all P ＞ 0.05).Mter 3 months treatment,there was statistical difference in the level of serum phosphorus in the HD group.In the HDF group,there were significantly statistical differences of the levels of serum phosphorus,iPTH and ALP(all P ＜ 0.01).Compare with the HD group,the levels of serum phosphorus,ALP and iPTH in the HDF group were significant differences(all P ＜ 0.05).Conclusion Compared with HD,on-line HDF can effectively remove serum phosphorus and decrease iPTH and ALP,thus improve the abnormal mineral metabolism of maintenance hemodialysis patients with uremia.
