国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2015年
1期
50-52
,共3页
造血干细胞移植%肝静脉闭塞病%炎症%细胞因子类
造血榦細胞移植%肝靜脈閉塞病%炎癥%細胞因子類
조혈간세포이식%간정맥폐새병%염증%세포인자류
Hematopoietic stem cell transplantation%Hepatic veno-occlusive disease%Inflammation%Cytokines
肝静脉闭塞病(HVOD)是造血干细胞移植(HSCT)后的严重肝脏损伤并发症,典型HVOD一般发生在HSCT后1个月内.HVOD的发生机制迄今尚未完全清楚,其中炎症是影响HVOD的常见因素之一.炎症是以固有免疫细胞活化、分泌白细胞介素(IL)-1α,-1β及肿瘤坏死因子(TNF)-α等促炎因子为特征的损伤性反应,而炎性复合体是促炎因子水解活化的蛋白平台,可间接影响炎性损伤程度.笔者拟就炎性复合体在HSCT后HVOD发生中的研究进展进行综述如下.
肝靜脈閉塞病(HVOD)是造血榦細胞移植(HSCT)後的嚴重肝髒損傷併髮癥,典型HVOD一般髮生在HSCT後1箇月內.HVOD的髮生機製迄今尚未完全清楚,其中炎癥是影響HVOD的常見因素之一.炎癥是以固有免疫細胞活化、分泌白細胞介素(IL)-1α,-1β及腫瘤壞死因子(TNF)-α等促炎因子為特徵的損傷性反應,而炎性複閤體是促炎因子水解活化的蛋白平檯,可間接影響炎性損傷程度.筆者擬就炎性複閤體在HSCT後HVOD髮生中的研究進展進行綜述如下.
간정맥폐새병(HVOD)시조혈간세포이식(HSCT)후적엄중간장손상병발증,전형HVOD일반발생재HSCT후1개월내.HVOD적발생궤제흘금상미완전청초,기중염증시영향HVOD적상견인소지일.염증시이고유면역세포활화、분비백세포개소(IL)-1α,-1β급종류배사인자(TNF)-α등촉염인자위특정적손상성반응,이염성복합체시촉염인자수해활화적단백평태,가간접영향염성손상정도.필자의취염성복합체재HSCT후HVOD발생중적연구진전진행종술여하.
Hepatic veno-occlusive disease (HVOD) is one of the serious liver injury complications,and typical HVOD generally occurred within one month after hematopoietic stem cell transplantation (HSCT).The mechanism of HVOD is not entirely clear so far,and inflammation is one of the common factors affecting the HVOD.Inflammation is a response characteristic for injury,which depends on the innate immune cell activating and secreting interleukin (IL)-1α,-1β and tumor necrosis factor (IFN)-α.The inflammasome is the platform for proinflammatory cytokine hydrolysis activation,and determines the inflammatory injury degree.This review expounds research progress of inflammasomes in liver damage after HSCT.
