国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2015年
1期
61-65
,共5页
多发性骨髓瘤%免疫,细胞%免疫,体液%抗体,单克隆%放射免疫疗法%免疫调节
多髮性骨髓瘤%免疫,細胞%免疫,體液%抗體,單剋隆%放射免疫療法%免疫調節
다발성골수류%면역,세포%면역,체액%항체,단극륭%방사면역요법%면역조절
Multiple myeloma%Immunity,cellular%Immunity,humoral%Antibodies,monoclonal%Radioimmunotherapy%Immunomodulation
多发性骨髓瘤(MM)的发生、发展与机体免疫功能缺陷密切相关.传统的化疗多注重于直接杀伤MM细胞,患者接受化疗后不良反应较大,生活质量较低.更为重要的是,绝大多数MM患者接受化疗后,疾病进展或复发.免疫治疗因其导致的不良反应少,靶向性强,而有望成为治愈MM的新型治疗手段.笔者拟就有关MM免疫治疗的细胞免疫治疗、体液免疫治疗、放射免疫治疗及免疫调节剂4个方面的现状及进展进行综述.
多髮性骨髓瘤(MM)的髮生、髮展與機體免疫功能缺陷密切相關.傳統的化療多註重于直接殺傷MM細胞,患者接受化療後不良反應較大,生活質量較低.更為重要的是,絕大多數MM患者接受化療後,疾病進展或複髮.免疫治療因其導緻的不良反應少,靶嚮性彊,而有望成為治愈MM的新型治療手段.筆者擬就有關MM免疫治療的細胞免疫治療、體液免疫治療、放射免疫治療及免疫調節劑4箇方麵的現狀及進展進行綜述.
다발성골수류(MM)적발생、발전여궤체면역공능결함밀절상관.전통적화료다주중우직접살상MM세포,환자접수화료후불량반응교대,생활질량교저.경위중요적시,절대다수MM환자접수화료후,질병진전혹복발.면역치료인기도치적불량반응소,파향성강,이유망성위치유MM적신형치료수단.필자의취유관MM면역치료적세포면역치료、체액면역치료、방사면역치료급면역조절제4개방면적현상급진전진행종술.
The onset and development of multiple myeloma (MM) are closely related to immunodeficiency of the host.Traditional chemotherapy eradicates MM cells directly through inducing cell death,resulting in many side effects and poor quality of life.However,MM remains incurable and will eventually become resistant to chemotherapy,and progression or relapse is inevitable.The immunotherapy represents a novel therapeutic approach with few side effects and good targeting capability.This article reviews literatures on clinical data evaluating 4 major immunotherapeutic approaches for MM,including cellular immunotherapy,humoral immunotherapy,radioimmunotherapy and immunomodulation.
