国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2015年
1期
78-80
,共3页
高迁移率族蛋白1%白血病%淋巴瘤%多发性骨髓瘤
高遷移率族蛋白1%白血病%淋巴瘤%多髮性骨髓瘤
고천이솔족단백1%백혈병%림파류%다발성골수류
HMGB1 protein%Leukemia%Lymphoma%Multiple myeloma
高迁移率族蛋白B1(HMGB1)是存在于真核生物细胞核中的非组蛋白染色体结合蛋白.前期研究证明,HMGB1作为炎症晚期介质,参与炎症的发展.近年,HMGB1被发现高表达于多种恶性血液病中,并通过多种途径参与恶性血液病的发展和耐药等过程.笔者拟就HMGB1与肿瘤耐药、白血病、淋巴瘤及多发性骨髓瘤之间的关系进行综述,旨在为恶性血液病的治疗提供新靶点.
高遷移率族蛋白B1(HMGB1)是存在于真覈生物細胞覈中的非組蛋白染色體結閤蛋白.前期研究證明,HMGB1作為炎癥晚期介質,參與炎癥的髮展.近年,HMGB1被髮現高錶達于多種噁性血液病中,併通過多種途徑參與噁性血液病的髮展和耐藥等過程.筆者擬就HMGB1與腫瘤耐藥、白血病、淋巴瘤及多髮性骨髓瘤之間的關繫進行綜述,旨在為噁性血液病的治療提供新靶點.
고천이솔족단백B1(HMGB1)시존재우진핵생물세포핵중적비조단백염색체결합단백.전기연구증명,HMGB1작위염증만기개질,삼여염증적발전.근년,HMGB1피발현고표체우다충악성혈액병중,병통과다충도경삼여악성혈액병적발전화내약등과정.필자의취HMGB1여종류내약、백혈병、림파류급다발성골수류지간적관계진행종술,지재위악성혈액병적치료제공신파점.
High mobility group protein B1 (HMGB1) belongs to non-histone chromosomal binding protein that exists in eukaryotic nuclei.Early studies have shown that HMGB1 acted as a late inflammatory mediator involved in inflammation progress.In recent years,it is found highly expressed in many hematologic malignancies,and it participates in the development and drug resistance of hematologic malignancies through a variety of ways.This article reviews the relationship between HMGB1 and tumor multidrug resistance,leukemia,lymphoma and multiple myeloma,in order to provide a new target for clinical treatment of hematologic malignancies.
