国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2015年
1期
81-84
,共4页
抗体,双特异性%血液肿瘤%免疫疗法
抗體,雙特異性%血液腫瘤%免疫療法
항체,쌍특이성%혈액종류%면역요법
Antibodies,bispecific%Hematologic neoplasms%Immunotherapy
免疫治疗作为一种新的肿瘤治疗方法,其基础和临床研究已有大量文献报道.双特异性抗体(BsAb)作为含有2种特异性抗原结合位点的人工抗体,可诱导效应细胞靶向杀伤肿瘤细胞,具有良好的临床应用前景,如抗CD3/抗CD19 BsAb和抗CD33/抗CD3 BsAb等,目前已成为免疫治疗血液肿瘤的研究热点之一.笔者拟就基础及临床试验2个方面介绍BsAb在血液肿瘤治疗中的研究进展,旨在进一步探讨BsAb在血液肿瘤的应用潜能.
免疫治療作為一種新的腫瘤治療方法,其基礎和臨床研究已有大量文獻報道.雙特異性抗體(BsAb)作為含有2種特異性抗原結閤位點的人工抗體,可誘導效應細胞靶嚮殺傷腫瘤細胞,具有良好的臨床應用前景,如抗CD3/抗CD19 BsAb和抗CD33/抗CD3 BsAb等,目前已成為免疫治療血液腫瘤的研究熱點之一.筆者擬就基礎及臨床試驗2箇方麵介紹BsAb在血液腫瘤治療中的研究進展,旨在進一步探討BsAb在血液腫瘤的應用潛能.
면역치료작위일충신적종류치료방법,기기출화림상연구이유대량문헌보도.쌍특이성항체(BsAb)작위함유2충특이성항원결합위점적인공항체,가유도효응세포파향살상종류세포,구유량호적림상응용전경,여항CD3/항CD19 BsAb화항CD33/항CD3 BsAb등,목전이성위면역치료혈액종류적연구열점지일.필자의취기출급림상시험2개방면개소BsAb재혈액종류치료중적연구진전,지재진일보탐토BsAb재혈액종류적응용잠능.
Immunotherapy as a new oncotherapy method,there is a large number of literature was carried out from basic and clinical studies.As artificial antibodies contain two specific antigen binding sites,bispecific antibodies (BsAb) can induce effector cells targeted kill tumor cells with good prospects for clinical application,such as anti CD3/CD19 BsAb and anti CD33/CD3 BsAb.And BsAb has become a research hotspot in immunotherapy of hematologic neoplasms.The author intends to review the research progress of BsAb in the treatment of hematologic neoplasms from the aspects of basic research and clinical trials,in order to explore the potential application of BsAb in hematologic neoplasms.
