CAJ | 학술논문

肿瘤是困扰人类健康的世界难题,当今肿瘤治疗面临的主要问题是不能在肿瘤发生早期做出精确诊断,从而失去治疗的最佳时机,导致肿瘤患者的死亡率逐年增高;此外,肿瘤治疗药物的靶向性差,严重的毒副作用限制了临床应用.因此,设计并开发新型靶向肿瘤的药物载体迫在眉睫.研究表明,靶向纳米材料在肿瘤特异性诊断和治疗方面有极大的优越性.就靶向纳米材料、在肿瘤特异性诊断和靶向治疗方面的研究进展作一综述,并展望其发展前景.
종류시곤우인류건강적세계난제,당금종류치료면림적주요문제시불능재종류발생조기주출정학진단,종이실거치료적최가시궤,도치종류환자적사망솔축년증고;차외,종류치료약물적파향성차,엄중적독부작용한제료림상응용.인차,설계병개발신형파향종류적약물재체박재미첩.연구표명,파향납미재료재종류특이성진단화치료방면유겁대적우월성.취파향납미재료、재종류특이성진단화파향치료방면적연구진전작일종술,병전망기발전전경.
Tumor is still an unresolved health problem for human.The main obstacle for tumor cure is that precise diagnosis of tumor at the early stage can't be realized,which leads to the mortality increased year by year due to missing the best time of the treatment.Furthermore,lack of targeted ability and serious side effects of the medicine used for tumor treatment also limit the clinical application.Therefore,it is urgent to design and develop a novel targeted drug delivery vehicle.Recent studies show that targeted nanomaterials are superior on tumor-specific diagnosis and target therapy.This review will highlight the current advances in the targeted nanomaterials effect on tumor diagnosis and treatment in recent years and prospect the foreground of future development.