CAJ | 학술논문

传统观点认为,代谢异常及血流动力学障碍是糖尿病肾病的主要原因.近来研究认为,天然免疫介导的慢性、低水平炎性反应在糖尿病肾病的发生及发展中起核心作用.细胞黏附分子、生长因子、趋化因子和促炎细胞因子在糖尿病患者肾组织的表达增多,且血清和尿中的细胞因子和黏附分子的水平与白蛋白尿相关.研究发现一些抗炎药物在糖尿病动物模型中有肾保护作用.因此深入了解糖尿病肾病的发病机制,并转化到临床开发相应的治疗策略,将可延缓甚至阻止糖尿病肾病的发生和发展.
전통관점인위,대사이상급혈류동역학장애시당뇨병신병적주요원인.근래연구인위,천연면역개도적만성、저수평염성반응재당뇨병신병적발생급발전중기핵심작용.세포점부분자、생장인자、추화인자화촉염세포인자재당뇨병환자신조직적표체증다,차혈청화뇨중적세포인자화점부분자적수평여백단백뇨상관.연구발현일사항염약물재당뇨병동물모형중유신보호작용.인차심입료해당뇨병신병적발병궤제,병전화도림상개발상응적치료책략,장가연완심지조지당뇨병신병적발생화발전.
Traditional opinions suggest that metabolic disorder and hemodynamic alterations are the critical causes of diabetic nephropathy.However,recent studies indicate that a chronic low-grade inflammation and an activation of the immune system are involved in development and progression of diabetic nephropathy.Expression of cell adhesion molecules,growth factors,chemokines and pro-inflammatory cytokines are increased in renal tissues of diabetic patients,and serum,urinary cytokines and cell adhesion molecules correlate with albuminuria.Several kinds of drugs that have anti-inflammatory actions show renal protective effects in diabetic animals.Therefore,investigating the role of inflammation in the development of diabetic nephropathy and translating it into new therapeutic strategies may be helpful in the prevention and treatment of diabetic nephropathy.