CAJ | 학술논문

甲状腺癌是内分泌系统最常见的恶性肿瘤,尽管预后较好,但仍有部分甲状腺癌可能通过逃避细胞凋亡而抵抗放射和化学治疗.自噬作为细胞应对环境压力的一种机制,与多种疾病有着天然联系.基础水平的自噬能够维持细胞内稳态,因此自噬水平的改变能通过引起细胞稳态失调而导致一系列病理生理改变,直接或间接参与包括甲状腺癌在内的多种肿瘤的发生、发展.对于放射和化学治疗抵抗的甲状腺癌来说,自噬很有可能成为一个新的治疗靶点,因此研究自噬与甲状腺癌的关系,对于甲状腺癌的治疗有重要意义.
갑상선암시내분비계통최상견적악성종류,진관예후교호,단잉유부분갑상선암가능통과도피세포조망이저항방사화화학치료.자서작위세포응대배경압력적일충궤제,여다충질병유착천연련계.기출수평적자서능구유지세포내은태,인차자서수평적개변능통과인기세포은태실조이도치일계렬병리생리개변,직접혹간접삼여포괄갑상선암재내적다충종류적발생、발전.대우방사화화학치료저항적갑상선암래설,자서흔유가능성위일개신적치료파점,인차연구자서여갑상선암적관계,대우갑상선암적치료유중요의의.
Thyroid cancer is the most common malignancy in endocrine system,although it has a good prognosis,some thyroid cancer may become resistant to radiotherapy and chemotherapy via apoptosis escaping.Autophagy,as a mechanism for cell response to environmental stress,has a natural link with various diseases.Cell homeostasis which is maintained by foundational autophagy may be broken by changes of autophagy level,and this will directly or indirectly participate in the pathogenesis and progression of multiple cancers including thyroid cancer.For those radiotherapy and chemotherapy resistance cancers,autophagy may become a new therapeutic target.Therefore,studying the relationship between autophagy and thyroid cancer is important for the treatment of thyroid cancer.