CAJ | 학술논문

近年来,男性迟发型性腺功能减退症(LOH)成为全球研究的热点.对勃起功能障碍、下丘脑/垂体病变、肥胖、代谢综合征、2型糖尿病、人类免疫缺陷病毒感染者等高危人群,应进行LOH筛查,若出现3种或3种以上性功能减退症状,且伴随血清总睾酮＜ 11 nmol/L及游离睾酮＜225pmol/L,可诊断为LOH.LOH主要依赖药物治疗,尤其是雄激素制剂.对于LOH合并肥胖、2型糖尿病、代谢综合征的患者,提倡生活方式干预.对有生育需求的患者,可考虑促性腺激素或促性腺激素释放激素的脉冲式治疗.对无生育要求的患者,睾酮替代是治疗LOH的金标准.
근년래,남성지발형성선공능감퇴증(LOH)성위전구연구적열점.대발기공능장애、하구뇌/수체병변、비반、대사종합정、2형당뇨병、인류면역결함병독감염자등고위인군,응진행LOH사사,약출현3충혹3충이상성공능감퇴증상,차반수혈청총고동＜ 11 nmol/L급유리고동＜225pmol/L,가진단위LOH.LOH주요의뢰약물치료,우기시웅격소제제.대우LOH합병비반、2형당뇨병、대사종합정적환자,제창생활방식간예.대유생육수구적환자,가고필촉성선격소혹촉성선격소석방격소적맥충식치료.대무생육요구적환자,고동체대시치료LOH적금표준.
In the past few years,late-onset hypogonadism (LOH) in men has been extensively studied.Subjects with erectile dysfunction,hypothalamic/pituitary diseases,obesity,metabolic syndrome,type 2 diabetes mellitus (T2DM),human immunodeficiency virus infection should evaluate LOH.The presence of at least three hypogonadism symptoms along with a reduced testosterone level (less than 11 nmol/L) and a decreased free testosterone level (less than 225 pmoL/L) is considered as the minimum criteria for the diagnosis of LOH.Drug therapy,especially androgenic hormone,is mainly used in the treatment of LOH.Lifestyle modification should be strongly encouraged in hypogonadal subjects with obesity,T2DM and metabolic syndrome.Gonadotropin or pulsatile gonadotropin releasing hormone maybe recommended for those with the need of fertility,where as testosterone replacement therapy is the golden treatment for those without.