CAJ | 학술논문

目的探讨乳腺癌组织中热休克蛋白5(HSPA5)的表达及其与乳腺癌临床病理因素的关系.方法对乳腺癌手术切除标本中的癌组织97例以及其中带有癌旁正常组织的标本40例,用免疫组织化学二步法检测HSPA5蛋白表达情况.结果 HSPA5在97例乳腺癌中的阳性表达率为81.4％(79/97).在所选取的40例乳腺癌及癌旁正常组织中,HSPA5的阳性表达率分别为32.5％(13/40)、7.5％(3/40),差异有统计学意义(x 2=7.813,P=0.038).HSPA5在不同组织学类型及不同肿瘤直径乳腺癌中的表达差异均无统计学意义(x2=5.785、1.500,P=0.056、0.296);而在不同组织学分级和有无淋巴结转移的乳腺癌中,表达差异有统计学意义(x2=22.233、5.342,P=0.007、0.024).结论 HSPA5的在乳腺癌组织中高表达,可能与乳腺癌的发生、发展和浸润转移有关,对于判断乳腺癌的临床预后有重要意义.
목적 탐토유선암조직중열휴극단백5(HSPA5)적표체급기여유선암림상병리인소적관계.방법 대유선암수술절제표본중적암조직97례이급기중대유암방정상조직적표본40례,용면역조직화학이보법검측HSPA5단백표체정황.결과 HSPA5재97례유선암중적양성표체솔위81.4％(79/97).재소선취적40례유선암급암방정상조직중,HSPA5적양성표체솔분별위32.5％(13/40)、7.5％(3/40),차이유통계학의의(x 2=7.813,P=0.038).HSPA5재불동조직학류형급불동종류직경유선암중적표체차이균무통계학의의(x2=5.785、1.500,P=0.056、0.296);이재불동조직학분급화유무림파결전이적유선암중,표체차이유통계학의의(x2=22.233、5.342,P=0.007、0.024).결론 HSPA5적재유선암조직중고표체,가능여유선암적발생、발전화침윤전이유관,대우판단유선암적림상예후유중요의의.
Objective To investigate the expression of heat shock protein 5 (HSPA5) in breast carcinoma and to study its relationship with clinical and pathological factors.Methods HSPA5 from 97 cases of breast carcinoma and 40 cases of adjacent tissues of breast carcinoma were examined by immunohistochemical method.Results The overall positive rate of HSPA5 in 97 cases of breast cancer was 81.4 ％ (79/97).The positive rates of HSPA5 in cancer tissues and paired normal tissues were 32.5 ％ (13/40) and 7.5 ％ (3/40),respectively.The expression rate of HSPA5 in tumor tissues was significantly higher than that in normal tissues (x2 =7.813,P =0.038).The expression of HSPA5 in breast carcinoma was correlated with histologic grade and lymph node metastasis (x2 =22.233,P =0.007; x2 =5.342,P =0.024).Conclusion The occurrence of breast carcinoma and the formation of invasion may be related with overexperssion of HSPA5.