肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2014年
12期
851-853
,共3页
微小RNA%miR-34b%p53%甲基化%肿瘤
微小RNA%miR-34b%p53%甲基化%腫瘤
미소RNA%miR-34b%p53%갑기화%종류
MicroRNA%miR-34b%p53%Methylation%Neoplasms
miRNA是一种内源性的非编码小RNA,在转录后水平调控基因表达,具有高度保守性和组织特异性.其广泛参与调控细胞的生长、发育等许多复杂生命过程,在多种肿瘤的发病中起重要作用.miR-34b为新近发现并备受关注的miRNA之一,受p53及其启动子甲基化等因素的调节,并通过调控多种靶分子参与调节细胞的增殖与凋亡,对肿瘤的发生与调控起作用,在肿瘤的治疗与预后中有广阔的应用前景.文章就miR-34b及其与肿瘤关系的研究进展进行综述.
miRNA是一種內源性的非編碼小RNA,在轉錄後水平調控基因錶達,具有高度保守性和組織特異性.其廣汎參與調控細胞的生長、髮育等許多複雜生命過程,在多種腫瘤的髮病中起重要作用.miR-34b為新近髮現併備受關註的miRNA之一,受p53及其啟動子甲基化等因素的調節,併通過調控多種靶分子參與調節細胞的增殖與凋亡,對腫瘤的髮生與調控起作用,在腫瘤的治療與預後中有廣闊的應用前景.文章就miR-34b及其與腫瘤關繫的研究進展進行綜述.
miRNA시일충내원성적비편마소RNA,재전록후수평조공기인표체,구유고도보수성화조직특이성.기엄범삼여조공세포적생장、발육등허다복잡생명과정,재다충종류적발병중기중요작용.miR-34b위신근발현병비수관주적miRNA지일,수p53급기계동자갑기화등인소적조절,병통과조공다충파분자삼여조절세포적증식여조망,대종류적발생여조공기작용,재종류적치료여예후중유엄활적응용전경.문장취miR-34b급기여종류관계적연구진전진행종술.
miRNA is a kind of small,endogenous noncoding RNA which regulates gene expression in post-transcription level and is highly conserved and tissue-specificity,miRNA generally participates the regulation of many complicated vital process,such as cell growth,development and also plays an important role in the pathogenesis of many kinds of tumors,miR-34b is a newly discovered miRNA,which is regulated by p53,promoter methylation and so on.miR-34b can regulate cellular proliferation and apoptosis,and also involves in the generation and regulation of tumor,which suggests wide application prospect in therapy and prognosis of tumor.This review will focus on the progress of miR-34b and its relationship with tumor.
