CAJ | 학술논문

近年来丹参酮ⅡA的抗肿瘤作用备受关注,体外研究证实丹参酮ⅡA对多种细胞具有细胞毒性并可诱导细胞分化和凋亡,但其体内抗肿瘤作用及机制尚未被阐明.丹参酮ⅡA剂量差异大,用药途径有灌胃、皮下注射、腹腔注射和静脉注射等,疗程不等.水溶性差、肠道吸收差、口服生物利用度差等影响了丹参酮ⅡA的应用,这些也是下一步研究丹参酮ⅡA方向.
근년래단삼동ⅡA적항종류작용비수관주,체외연구증실단삼동ⅡA대다충세포구유세포독성병가유도세포분화화조망,단기체내항종류작용급궤제상미피천명.단삼동ⅡA제량차이대,용약도경유관위、피하주사、복강주사화정맥주사등,료정불등.수용성차、장도흡수차、구복생물이용도차등영향료단삼동ⅡA적응용,저사야시하일보연구단삼동ⅡA방향.
Tanshinone Ⅱ A is effective to treat a great variety of diseases,and recently its potential anticancer activity has attracted great attention.While studies in vitro indicate that tanshinone Ⅱ A is toxic in a number of cell types and affects differentiation and apoptosis,but anticancer effects in vivo remain to be elucidated.Tanshinone Ⅱ A varies widely in production quality,method of administration (oral,intravenous,subcutaneous,and so on),usage and dosage.Tanshinone Ⅱ A" s limited hydrophilicity,poor intestinal absorption,low oral efficacy,and other pharmacologic characteristics have impacted both its usage and elucidation of efficacy and mechanisms in vivo,which are the focus of future research.