CAJ | 학술논문

目的探讨人类不同年龄组正常主涎腺磁共振成像(MRI)体积、信号强度及表观扩散系数(ADC)值的增龄变化规律.方法回顾分析2009至2014年间苏州大学附属第二医院行常规头颈部MRI检查、无涎腺疾病的患者300例,测量4个年龄组共300例受试者600侧腮腺、颌下腺、舌下腺的体积、T1WI、T2WI信号强度与ADC值.以脑脊液为对照,计算各涎腺的相对信号强度(RSI).结果腮腺的体积、T1WI RSI、T2WI RSI和舌下腺的T2WI RSI与年龄有相关性(P＜0.01).腮腺体积、T1WI RSI、T2WI RSI在老年期之前逐渐升高,老年期后有所下降,其中未成年组与中年组的差异有统计学意义(P＜0.01).只有未成年组与中年组颌下腺的ADC值差异有统计学意义(P＜0.01).结论 MRI能有效评价正常涎腺结构与功能的增龄性改变,可以为老龄化研究和涎腺疾病的评估提供基线参考依据,具有较高的临床价值.
목적 탐토인류불동년령조정상주연선자공진성상(MRI)체적、신호강도급표관확산계수(ADC)치적증령변화규률.방법 회고분석2009지2014년간소주대학부속제이의원행상규두경부MRI검사、무연선질병적환자300례,측량4개년령조공300례수시자600측시선、합하선、설하선적체적、T1WI、T2WI신호강도여ADC치.이뇌척액위대조,계산각연선적상대신호강도(RSI).결과 시선적체적、T1WI RSI、T2WI RSI화설하선적T2WI RSI여년령유상관성(P＜0.01).시선체적、T1WI RSI、T2WI RSI재노년기지전축점승고,노년기후유소하강,기중미성년조여중년조적차이유통계학의의(P＜0.01).지유미성년조여중년조합하선적ADC치차이유통계학의의(P＜0.01).결론 MRI능유효평개정상연선결구여공능적증령성개변,가이위노령화연구화연선질병적평고제공기선삼고의거,구유교고적림상개치.
Objective To analyze the age-related characteristics of volumes,signal intensities (SIs) of T1-weighted images (T1WI),T2-weighted images (T2WI) and apparent diffusion coefficients (ADCs) of three major salivary glands.Methods A total of 300 subjects with normal salivary glands were divided into 4 different age groups and examined with a 1.5 T magnetic resonance (MR) unit.T1 WI,T2WI and diffusion-weighted MR images (DW MRI) were obtained and bilateral parotid,submandibular and sublingual glands segmented manually.The volumes,T1 WI,T2 WI SIs and ADCs of three major salivary glands were measured.And the relative SIs (RSIs) were assessed by comparing with cerebrospinal fluid.Results The volumes,T1WI and T2WI RSIs of parotid glands were significantly correlated with age (P ＜0.01) and showed similar significant tendencies of growing from minority to middle age and decreasing slightly after old age.Significant differences existed between minority and middle age groups in all abovementioned parameters (P ＜ 0.01).The ADCs of submandibular glands also showed that there was a significant difference between the minority and middle age groups (P ＜ 0.01).Conclusion MRI may be applied for studying the morphological and functional changes of normal major salivary glands with aging.Thus clinical rationales can be provided for assessing the subjects of any age during salivary gland imaging and aging-related researches.