中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2015年
1期
23-25
,共3页
郭玉娜%匡梦华%刘伟%陈焱
郭玉娜%劻夢華%劉偉%陳焱
곽옥나%광몽화%류위%진염
先兆子痫%白细胞介素-10%肿瘤坏死因子α%细胞因子信号转导负调控因子
先兆子癇%白細胞介素-10%腫瘤壞死因子α%細胞因子信號轉導負調控因子
선조자간%백세포개소-10%종류배사인자α%세포인자신호전도부조공인자
Preeclampsia%Interleukin-10%Tumor necrosis factor-alpha%Suppressor of cytokine signaling 3
目的 研究子痫前期孕妇血清细胞因子信号转导负调控因子(SOCS)3、肿瘤坏死因子(TNF)-α及白细胞介素(IL)-10水平及临床价值.方法 将2012年1月至2013年12月在上海交通大学医学院附属国际和平妇幼保健院确诊的40例子痫前期孕妇纳入研究的观察组,同期在上海交通大学医学院附属国际和平妇幼保健院分娩的无妊娠并发症的40例孕妇纳入研究的对照组,检测血清中SOCS3、TNF-α、IL-10的含量并分析其相关性.结果 (1)观察组与对照组孕妇血清中SOCS3的mRNA含量分别为38 ±6、100±16;IL-10的mRNA含量分别为41±7、100±15;TNF-α的mRNA含量分别为226±40、100±19;(2)观察组孕妇血清中SOCS3、IL-10的蛋白含量低于对照组孕妇(P＜0.05),TNF-α的蛋白含量高于对照组孕妇(P ＜0.05);(3) SOCS3的mRNA含量和蛋白含量分别与TNF-α的mRNA含量和蛋白含量呈负相关,分别与IL-10的mRNA含量和蛋白含量呈正相关.结论 子痫前期孕妇血清中SOCS3含量显著降低,进而导致抑制Th1型细胞因子TNF-α表达和促进Th2型细胞因子IL-10表达的作用减弱,在疾病的发生过程中发挥重要作用.
目的 研究子癇前期孕婦血清細胞因子信號轉導負調控因子(SOCS)3、腫瘤壞死因子(TNF)-α及白細胞介素(IL)-10水平及臨床價值.方法 將2012年1月至2013年12月在上海交通大學醫學院附屬國際和平婦幼保健院確診的40例子癇前期孕婦納入研究的觀察組,同期在上海交通大學醫學院附屬國際和平婦幼保健院分娩的無妊娠併髮癥的40例孕婦納入研究的對照組,檢測血清中SOCS3、TNF-α、IL-10的含量併分析其相關性.結果 (1)觀察組與對照組孕婦血清中SOCS3的mRNA含量分彆為38 ±6、100±16;IL-10的mRNA含量分彆為41±7、100±15;TNF-α的mRNA含量分彆為226±40、100±19;(2)觀察組孕婦血清中SOCS3、IL-10的蛋白含量低于對照組孕婦(P＜0.05),TNF-α的蛋白含量高于對照組孕婦(P ＜0.05);(3) SOCS3的mRNA含量和蛋白含量分彆與TNF-α的mRNA含量和蛋白含量呈負相關,分彆與IL-10的mRNA含量和蛋白含量呈正相關.結論 子癇前期孕婦血清中SOCS3含量顯著降低,進而導緻抑製Th1型細胞因子TNF-α錶達和促進Th2型細胞因子IL-10錶達的作用減弱,在疾病的髮生過程中髮揮重要作用.
목적 연구자간전기잉부혈청세포인자신호전도부조공인자(SOCS)3、종류배사인자(TNF)-α급백세포개소(IL)-10수평급림상개치.방법 장2012년1월지2013년12월재상해교통대학의학원부속국제화평부유보건원학진적40례자간전기잉부납입연구적관찰조,동기재상해교통대학의학원부속국제화평부유보건원분면적무임신병발증적40례잉부납입연구적대조조,검측혈청중SOCS3、TNF-α、IL-10적함량병분석기상관성.결과 (1)관찰조여대조조잉부혈청중SOCS3적mRNA함량분별위38 ±6、100±16;IL-10적mRNA함량분별위41±7、100±15;TNF-α적mRNA함량분별위226±40、100±19;(2)관찰조잉부혈청중SOCS3、IL-10적단백함량저우대조조잉부(P＜0.05),TNF-α적단백함량고우대조조잉부(P ＜0.05);(3) SOCS3적mRNA함량화단백함량분별여TNF-α적mRNA함량화단백함량정부상관,분별여IL-10적mRNA함량화단백함량정정상관.결론 자간전기잉부혈청중SOCS3함량현저강저,진이도치억제Th1형세포인자TNF-α표체화촉진Th2형세포인자IL-10표체적작용감약,재질병적발생과정중발휘중요작용.
Objective To explore the serum levels of suppressor of cytokine signaling 3 (SOCS3),tumor necrosis factor-alpha (TNF-ot) and interleukin-10 (IL-10) in preeclampsia mothers and determine their clinical values.Methods A total of 40 preeclampsia mothers at International Peace Maternity and Child Health Hospital of China Welfare Institute Affiliated to Shanghai Jiaotong University from March 2011 to August 2013 were enrolled into observation group.Another 40 cases of mothers without pregnancy complications were selected as control group.Then the serum contents of SOCS3,TNF-α and IL-10 were detected and their correlations analyzed.Results (1) The mRNA levels of SOCS3 of observation and control groups were 38 ± 6and 100 ± 16while the mRNA levels of TNF-α 226 ± 40 and 100 ± 19 respectively; (2)the proteins levels of SOCS3 of observation group were lower than those of control group (P ＜ 0.05) while the proteins levels of TNF-α of observation group were higher than those of control group (P ＜ 0.05) ; (3) the mRNA and protein contents of SOCS3 were negatively correlated with mRNA and protein contents of TNF-α and positively correlated with IL-10.Conclusion The serum content of SOCS3 decreases significantly in preeclampsia so that there is a down-regulation of Th1 type cytokine TNF-α and an up-regulation of Th2 type cytokine IL-10.And it may play an important role in the occurrence of disease.
