中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2015年
1期
69-72
,共4页
特发性震颤%患病率%危险因素%病例对照研究
特髮性震顫%患病率%危險因素%病例對照研究
특발성진전%환병솔%위험인소%병례대조연구
Essential tremor%Prevalence%Risk factors%Case-control study
目的 研究新疆维吾尔自治区和田地区维吾尔族常住居民特发性震颤(ET)的患病率及发病相关因素.方法 运用整群随机抽样方法,在和田地区7县1市中随机抽取和田市、于田县、墨玉县及洛浦县年龄在45岁及以上的常住居民(≥10年)进行流行病学问卷调查;按ET诊断标准筛选ET患者并计算其患病率;采用病例对照研究,按1∶1随机选出未患ET的健康人群作为对照组,且与病例组在性别、族别、年龄(±2岁)方面相匹配.采用结构式问卷,以面对面方式调查了解ET发病的相关因素.对数据采用EpiData 3.1软件两人独立录入,分析和田地区各年龄组的ET的患病率,并运用SPSS19.0统计软件对各研究因素与ET的关系进行多因素条件性Logistic回归分析,P＜0.05差异有统计学意义.结果 和田地区2013年11至12月共有5 932例人接受问卷调查,其中发现ET患者216例,且均为维吾尔族,该地区45岁以上ET的总患病率3.64％,其中45岁以上男性患病率为3.76％,女性患病率为3.52％.45 ～ 54岁、55 ～ 64岁、65 ～ 74岁、75岁以上人群的患病率分别为3.08％、3.72％、4.08％、4.31％.多因素条件性Logistic回归分析显示:农药接触史(B=2.664,x2=86.773,P＜0.05,OR=14.347,95％ CI8.192～25.127)、家族史(B=3.191,x2 =61.430,P＜0.05,OR=24.303,95％ CI 10.943 ～ 53.972)可增加ET的发病风险;而职业、文化程度、运动及社会活动、饮茶、饮食习惯与ET发病无明显相关性.结论 新疆维吾尔自治区和田地区45岁以上ET患病率为3.76％,且随着年龄的增长,ET患病率呈增高趋势.该地区ET发病可能与年龄、农药接触史及家族史密切相关,并为该地区ET早期预防及诊治提供理论依据.
目的 研究新疆維吾爾自治區和田地區維吾爾族常住居民特髮性震顫(ET)的患病率及髮病相關因素.方法 運用整群隨機抽樣方法,在和田地區7縣1市中隨機抽取和田市、于田縣、墨玉縣及洛浦縣年齡在45歲及以上的常住居民(≥10年)進行流行病學問捲調查;按ET診斷標準篩選ET患者併計算其患病率;採用病例對照研究,按1∶1隨機選齣未患ET的健康人群作為對照組,且與病例組在性彆、族彆、年齡(±2歲)方麵相匹配.採用結構式問捲,以麵對麵方式調查瞭解ET髮病的相關因素.對數據採用EpiData 3.1軟件兩人獨立錄入,分析和田地區各年齡組的ET的患病率,併運用SPSS19.0統計軟件對各研究因素與ET的關繫進行多因素條件性Logistic迴歸分析,P＜0.05差異有統計學意義.結果 和田地區2013年11至12月共有5 932例人接受問捲調查,其中髮現ET患者216例,且均為維吾爾族,該地區45歲以上ET的總患病率3.64％,其中45歲以上男性患病率為3.76％,女性患病率為3.52％.45 ～ 54歲、55 ～ 64歲、65 ～ 74歲、75歲以上人群的患病率分彆為3.08％、3.72％、4.08％、4.31％.多因素條件性Logistic迴歸分析顯示:農藥接觸史(B=2.664,x2=86.773,P＜0.05,OR=14.347,95％ CI8.192～25.127)、傢族史(B=3.191,x2 =61.430,P＜0.05,OR=24.303,95％ CI 10.943 ～ 53.972)可增加ET的髮病風險;而職業、文化程度、運動及社會活動、飲茶、飲食習慣與ET髮病無明顯相關性.結論 新疆維吾爾自治區和田地區45歲以上ET患病率為3.76％,且隨著年齡的增長,ET患病率呈增高趨勢.該地區ET髮病可能與年齡、農藥接觸史及傢族史密切相關,併為該地區ET早期預防及診治提供理論依據.
목적 연구신강유오이자치구화전지구유오이족상주거민특발성진전(ET)적환병솔급발병상관인소.방법 운용정군수궤추양방법,재화전지구7현1시중수궤추취화전시、우전현、묵옥현급락포현년령재45세급이상적상주거민(≥10년)진행류행병학문권조사;안ET진단표준사선ET환자병계산기환병솔;채용병례대조연구,안1∶1수궤선출미환ET적건강인군작위대조조,차여병례조재성별、족별、년령(±2세)방면상필배.채용결구식문권,이면대면방식조사료해ET발병적상관인소.대수거채용EpiData 3.1연건량인독립록입,분석화전지구각년령조적ET적환병솔,병운용SPSS19.0통계연건대각연구인소여ET적관계진행다인소조건성Logistic회귀분석,P＜0.05차이유통계학의의.결과 화전지구2013년11지12월공유5 932례인접수문권조사,기중발현ET환자216례,차균위유오이족,해지구45세이상ET적총환병솔3.64％,기중45세이상남성환병솔위3.76％,녀성환병솔위3.52％.45 ～ 54세、55 ～ 64세、65 ～ 74세、75세이상인군적환병솔분별위3.08％、3.72％、4.08％、4.31％.다인소조건성Logistic회귀분석현시:농약접촉사(B=2.664,x2=86.773,P＜0.05,OR=14.347,95％ CI8.192～25.127)、가족사(B=3.191,x2 =61.430,P＜0.05,OR=24.303,95％ CI 10.943 ～ 53.972)가증가ET적발병풍험;이직업、문화정도、운동급사회활동、음다、음식습관여ET발병무명현상관성.결론 신강유오이자치구화전지구45세이상ET환병솔위3.76％,차수착년령적증장,ET환병솔정증고추세.해지구ET발병가능여년령、농약접촉사급가족사밀절상관,병위해지구ET조기예방급진치제공이론의거.
Objective To explore the prevalence and related factors of essential tremor (ET)in permanent residents of Hetian,Xinjiang.Methods By cluster random sampling,the local residents (≥ 10 years) at the age of 45 years and above in Hetian,Xinjiang received an epidemiological survey covering 1 city and 7 counties.Hetian City,Yutian County,Moyu County and Luopu County were randomly selected.According to the diagnostic standard of ET,the ET patients were screened face-to-face to understand the factors related to the pathogenesis of ET.And for this case control study,a ratio of 1 ∶ 1 was used to randomly select healthy subjects without ET as the control group.Both groups were matched with regards to gender,nationality and age (±2 yr).The EpiData 3.1 software was employed.And the data were independently entered to analyze the prevalence of ET in various age groups.The statistical software SPSS 19.0 was used for single factor analysis and multivariate conditional Logistic regression analysis.P ＜ 0.05 was statistically significant.Results A total of 5 932 patients responded to the questionnaire and there were 216 cases of ET patients.The total prevalence rate of ET was 3.64％ in those aged over 45 years old and the prevalence rate over 45 years of age was 3.76％ for males and 3.52％ for females.The prevalence of 45-54,55-64,65-74 and ≥75-year old were 3.08％,3.72％,4.08％ and 4.31％ respectively.Multivariate conditional Logistic regression analysis showed:the pesticide exposure history (B =2.664,x2 =86.773,P ＜ 0.05,OR =14.347,95％ CI 8.192-25.127) and family history (B =3.191,x2 =61.430,P ＜ 0.05,OR =24.303,95％ CI 10.943-53.972) were associated with increased risk of ET while occupation,education,sports,social activities,drinking tea,eating habits and the incidence of ET had no obvious correlation.Conclusion ET has a prevalence rate of 3.64％ in Hetian,Xinjiang,And it has a rising trend with advancing age.The pathogenesis of ET is probably correlated with age,pesticide exposure history and family history.Thus theoretic rationales may be provided for early prevention and treatment of ET in the area.
