CAJ | 학술논문

微核试验能同时检测染色体畸变、DNA修复障碍、凋亡以及部分基因突变等多个遗传终点,已经成为肿瘤分子流行病学研究中的重要组成部分.本文从肿瘤的早期发现与诊断、致癌性物质的评价、遗传易感性生物标志物、微量营养素与肿瘤以及队列研究这五个方面简要综述了近年来微核试验在肿瘤分子流行病学中的应用.
미핵시험능동시검측염색체기변、DNA수복장애、조망이급부분기인돌변등다개유전종점,이경성위종류분자류행병학연구중적중요조성부분.본문종종류적조기발현여진단、치암성물질적평개、유전역감성생물표지물、미량영양소여종류이급대렬연구저오개방면간요종술료근년래미핵시험재종류분자류행병학중적응용.
The micronucleus test (MNT) can be used to detect multiple genetic end points simultaneously,including chromosome aberration,mis-repaired DNA damage,apoptosis,parts of mutation and so on,which MNT has been an important part of the study of cancer epidemiology.Here,we reviewed the progress of MNT in the field of molecular cancer epidemiology in recent years,including early detection and diagnosis of cancer,evaluation of carcinogenic substances,genetic susceptibility biomarkers,micronutrient and cohort studies.