CAJ | 학술논문

特发性肺纤维化是一种病因不明、发病机制不清、缺乏有效治疗手段的弥漫性肺间质疾病,以肺泡上皮损伤、成纤维细胞灶形成、细胞外基质积聚,最终导致肺泡结构异常重塑为病理特征.研究发现,γ干扰素(IFN-γ)能够通过调控信号通路、调控miRNA表达、调节血管再生等发挥抗肺纤维化作用.另有文献报道,IFN-γ可能具有致炎致纤维化的作用.本文针对内源性IFN-γ在特发性肺纤维化发病过程中的作用进行综述,为特发性肺纤维化的发病和治疗提供理论依据.
특발성폐섬유화시일충병인불명、발병궤제불청、결핍유효치료수단적미만성폐간질질병,이폐포상피손상、성섬유세포조형성、세포외기질적취,최종도치폐포결구이상중소위병리특정.연구발현,γ간우소(IFN-γ)능구통과조공신호통로、조공miRNA표체、조절혈관재생등발휘항폐섬유화작용.령유문헌보도,IFN-γ가능구유치염치섬유화적작용.본문침대내원성IFN-γ재특발성폐섬유화발병과정중적작용진행종술,위특발성폐섬유화적발병화치료제공이론의거.
Idiopathic pulmonary fibrosis (IPF) is a diffuse interstitial lung disease with unknown etiology and elusive pathogenesis,and no effective therapy has been shown to stop the progression of IPF.Pathologically,it is characterized by alveolar epithelial injury,fibroblast foci formation and extracellular matrix accumulation,which eventually leads to abnormal alveolar structure disorder and remodeling.It was reported that interferon-γ (IFN-γ) could repress the progression of IPF through regulating angiogenesis,the expression of miRNA and its related genes,and several important signaling pathways.However,some studies also uncovered that IFN-γ might induce the inflammation and fibrosis.Therefore,this paper reviews the roles of endogenous IFN-γ in the pathogenesis of IPF,which provides theoretical foundation for the etiology and therapy of IPF.