国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
2期
164-167,173
,共5页
同型半胱氨酸%生活方式%社区干预
同型半胱氨痠%生活方式%社區榦預
동형반광안산%생활방식%사구간예
Homocysteine%Lifestyle%Community intervention
目的 评价通过社区干预改变饮食及生活方式效果,探讨改变与高同型半胱氨酸血症相关生活方式对于高同型半胱氨酸血症患者血浆同型半胱氨酸水平的影响,为制定相关高同型半胱氨酸血症社区干预措施提供依据.方法 本次研究采用随机社区干预试验方法,以体检中发现的304位高同型半胱氨酸血症患者随机分配组成对照组和干预组,随访干预6月后采用卡方检验、t检验和方差分析比较两组生活方式和血浆同型半胱氨酸浓度等相关体检指标差异情况,了解饮食生活行为方式在降低血浆同型半胱氨酸的作用.结果 本次研究结果显示干预组干预前后及干预后干预组与对照组间生活方式有改变且有统计学意义,干预组干预前后同型半胱氨酸浓度分别为(18.62±7.02) mmol/L和(15.86±5.17) mmol/L,血浆同型半胱氨酸、甘油三酯和总胆固醇干预组干预前后比较差异有统计学意义(P＜0.05),干预组与对照组干预后比较差异有统计学意义(P＜0.05),空腹血糖、尿素氮和体质指数干预组干预前后比较及干预组与对照组干预后比较差异无统计学意义.结论 社区干预可有效改善生活方式,减少高同型半胱氨酸血症的相关危险因素、增加保护因素从而减少高同型半胱氨酸血症的发生、发展,继而降低因高同型半胱氨酸血症引起的相关疾病.
目的 評價通過社區榦預改變飲食及生活方式效果,探討改變與高同型半胱氨痠血癥相關生活方式對于高同型半胱氨痠血癥患者血漿同型半胱氨痠水平的影響,為製定相關高同型半胱氨痠血癥社區榦預措施提供依據.方法 本次研究採用隨機社區榦預試驗方法,以體檢中髮現的304位高同型半胱氨痠血癥患者隨機分配組成對照組和榦預組,隨訪榦預6月後採用卡方檢驗、t檢驗和方差分析比較兩組生活方式和血漿同型半胱氨痠濃度等相關體檢指標差異情況,瞭解飲食生活行為方式在降低血漿同型半胱氨痠的作用.結果 本次研究結果顯示榦預組榦預前後及榦預後榦預組與對照組間生活方式有改變且有統計學意義,榦預組榦預前後同型半胱氨痠濃度分彆為(18.62±7.02) mmol/L和(15.86±5.17) mmol/L,血漿同型半胱氨痠、甘油三酯和總膽固醇榦預組榦預前後比較差異有統計學意義(P＜0.05),榦預組與對照組榦預後比較差異有統計學意義(P＜0.05),空腹血糖、尿素氮和體質指數榦預組榦預前後比較及榦預組與對照組榦預後比較差異無統計學意義.結論 社區榦預可有效改善生活方式,減少高同型半胱氨痠血癥的相關危險因素、增加保護因素從而減少高同型半胱氨痠血癥的髮生、髮展,繼而降低因高同型半胱氨痠血癥引起的相關疾病.
목적 평개통과사구간예개변음식급생활방식효과,탐토개변여고동형반광안산혈증상관생활방식대우고동형반광안산혈증환자혈장동형반광안산수평적영향,위제정상관고동형반광안산혈증사구간예조시제공의거.방법 본차연구채용수궤사구간예시험방법,이체검중발현적304위고동형반광안산혈증환자수궤분배조성대조조화간예조,수방간예6월후채용잡방검험、t검험화방차분석비교량조생활방식화혈장동형반광안산농도등상관체검지표차이정황,료해음식생활행위방식재강저혈장동형반광안산적작용.결과 본차연구결과현시간예조간예전후급간예후간예조여대조조간생활방식유개변차유통계학의의,간예조간예전후동형반광안산농도분별위(18.62±7.02) mmol/L화(15.86±5.17) mmol/L,혈장동형반광안산、감유삼지화총담고순간예조간예전후비교차이유통계학의의(P＜0.05),간예조여대조조간예후비교차이유통계학의의(P＜0.05),공복혈당、뇨소담화체질지수간예조간예전후비교급간예조여대조조간예후비교차이무통계학의의.결론 사구간예가유효개선생활방식,감소고동형반광안산혈증적상관위험인소、증가보호인소종이감소고동형반광안산혈증적발생、발전,계이강저인고동형반광안산혈증인기적상관질병.
Objective To evaluate the effect of community intervention in changing diet and lifestyle,explore the effect in lowering plasma homocysteine level in patients with hyperhomocysteinemia by changing related lifestyle,and provide evidence for making community intervention.Methods Randomized controlled trial was used in this study.304 patients with hyperhomocysteinemia who were found by elderly medical examination were randomly divided into control group and intervention group,152 cases in each group.After six months' follow-up,we compared lifestyle and plasma homocysteine concentration of two groups with chi-square test,t test and variance analysis.Results There was statistically significant difference in lifestyle before and after intervention in intervention group,and between intervention group and control group.Plasma homocysteine concentration in intervention group before and after intervention were (18.62 ± 7.02) mmol/L and (15.86 ± 5.17) mmol/L respectively,with statistically significant difference (P ＜ 0.05).There were statistically significant differences in plasma homocysteine,triglyceride and total cholesterol in intervention group before and after intervention,and between intervention group and control group after six months' intervention (P ＜ 0.05).There were no statistically significant differences in fasting blood glucose,blood urea nitrogen and body mass index in intervention group before and after intervention,or between intervention group and control group after six months' intervention (P ＞ 0.05).Conclusion Community intervention can effectively improve lifestyles aiming at reducing risk factors and increasing protective factors to lower plasma homocysteine level in patients with hyperhomocysteinemia,and then reduce the incidence of diseases related to hyperhomocysteinemia.
