国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
1期
19-22
,共4页
古国宁%陈立新%余健全%邓敏
古國寧%陳立新%餘健全%鄧敏
고국저%진립신%여건전%산민
维生素D%高血压病%收缩压%舒张压%离散度
維生素D%高血壓病%收縮壓%舒張壓%離散度
유생소D%고혈압병%수축압%서장압%리산도
Vitamin D%Hypertension%Systolic pressure%Diastolic pressure%Discrete degree
目的 研究高血压病患者血浆维生素D(VitD)、D-二聚体(DD)含量与高血压患者脑静脉血栓形成的关联性,为高血压患者提供健康咨询意见.方法 将高血压患者分为运动组和普通组.用全自动免疫荧光分析法测定各组血浆DD含量,运用ELISA法测定患者血清VitD含量,分别统计各组数据;发放问卷调查患者生活习惯,将每周坚持户外运动不少于10公里者定义为运动组(A组50例),其余定义为普通组(B组50例);对所有患者进行头颅彩色多普勒超声检查,判断头部静脉血栓形成情况,分析该结果与VitD、DD含量的相关性;定期监测各组血压控制情况;追踪研究对象持续时间为1年,以评价VitD、DD含量与高血压患者血压控制、脑静脉血栓形成的关联性.另选50例健康体检者作为对照组(C组).结果 A组、B组、C组DD含量分别为(597±163)μg/L、(615±201) μg/L、(85±15)μg/L;A组、B组与对照组比较,差异有统计学意义(P＜0.05).A组、B组、C组收缩压分别为(144±16) mmHg、(145±27) mmHg、(115±6)mmHg,舒张压分别为(87±9)mmHg、(89±10) mmHg、(71±5)mmHg,收缩压变异系数(CVl)分别为11.4％、18.9％、6.7％,舒张压变异系数(CV2)分别为10.7％、12.0％、9.4％;A组、B组收缩压变异系数差异有统计学意义(P＜0.01),舒张压变异系数差异无统计学意义(P＞0.05).A组、B组、C组25羟基维生素D{25(OH)D}水平分别为(87.8±29.7)nmol/L、(34.9土18.9)nmol/L、(101.0±25.5)nmol/L,组间两两比较差异有统计学意义(P＜0.05);A组中2例脑静脉血栓患者及B组中6例脑静脉血栓患者血浆DD含量分别为(1067±189) μg/L、(1160±177) μg/L,差异无统计学意义(P＞0.05).结论 非运动组高血压患者普遍存在VitD含量不足或缺乏;运动组收缩压变化的离散程度较普通组明显收窄;两组舒张压的离散程度差异无统计学意义;脑部微血栓形成与血浆DD含量明显关联;适度运动有利于患者血压控制并有效减少患者脑部静脉微血栓形成.
目的 研究高血壓病患者血漿維生素D(VitD)、D-二聚體(DD)含量與高血壓患者腦靜脈血栓形成的關聯性,為高血壓患者提供健康咨詢意見.方法 將高血壓患者分為運動組和普通組.用全自動免疫熒光分析法測定各組血漿DD含量,運用ELISA法測定患者血清VitD含量,分彆統計各組數據;髮放問捲調查患者生活習慣,將每週堅持戶外運動不少于10公裏者定義為運動組(A組50例),其餘定義為普通組(B組50例);對所有患者進行頭顱綵色多普勒超聲檢查,判斷頭部靜脈血栓形成情況,分析該結果與VitD、DD含量的相關性;定期鑑測各組血壓控製情況;追蹤研究對象持續時間為1年,以評價VitD、DD含量與高血壓患者血壓控製、腦靜脈血栓形成的關聯性.另選50例健康體檢者作為對照組(C組).結果 A組、B組、C組DD含量分彆為(597±163)μg/L、(615±201) μg/L、(85±15)μg/L;A組、B組與對照組比較,差異有統計學意義(P＜0.05).A組、B組、C組收縮壓分彆為(144±16) mmHg、(145±27) mmHg、(115±6)mmHg,舒張壓分彆為(87±9)mmHg、(89±10) mmHg、(71±5)mmHg,收縮壓變異繫數(CVl)分彆為11.4％、18.9％、6.7％,舒張壓變異繫數(CV2)分彆為10.7％、12.0％、9.4％;A組、B組收縮壓變異繫數差異有統計學意義(P＜0.01),舒張壓變異繫數差異無統計學意義(P＞0.05).A組、B組、C組25羥基維生素D{25(OH)D}水平分彆為(87.8±29.7)nmol/L、(34.9土18.9)nmol/L、(101.0±25.5)nmol/L,組間兩兩比較差異有統計學意義(P＜0.05);A組中2例腦靜脈血栓患者及B組中6例腦靜脈血栓患者血漿DD含量分彆為(1067±189) μg/L、(1160±177) μg/L,差異無統計學意義(P＞0.05).結論 非運動組高血壓患者普遍存在VitD含量不足或缺乏;運動組收縮壓變化的離散程度較普通組明顯收窄;兩組舒張壓的離散程度差異無統計學意義;腦部微血栓形成與血漿DD含量明顯關聯;適度運動有利于患者血壓控製併有效減少患者腦部靜脈微血栓形成.
목적 연구고혈압병환자혈장유생소D(VitD)、D-이취체(DD)함량여고혈압환자뇌정맥혈전형성적관련성,위고혈압환자제공건강자순의견.방법 장고혈압환자분위운동조화보통조.용전자동면역형광분석법측정각조혈장DD함량,운용ELISA법측정환자혈청VitD함량,분별통계각조수거;발방문권조사환자생활습관,장매주견지호외운동불소우10공리자정의위운동조(A조50례),기여정의위보통조(B조50례);대소유환자진행두로채색다보륵초성검사,판단두부정맥혈전형성정황,분석해결과여VitD、DD함량적상관성;정기감측각조혈압공제정황;추종연구대상지속시간위1년,이평개VitD、DD함량여고혈압환자혈압공제、뇌정맥혈전형성적관련성.령선50례건강체검자작위대조조(C조).결과 A조、B조、C조DD함량분별위(597±163)μg/L、(615±201) μg/L、(85±15)μg/L;A조、B조여대조조비교,차이유통계학의의(P＜0.05).A조、B조、C조수축압분별위(144±16) mmHg、(145±27) mmHg、(115±6)mmHg,서장압분별위(87±9)mmHg、(89±10) mmHg、(71±5)mmHg,수축압변이계수(CVl)분별위11.4％、18.9％、6.7％,서장압변이계수(CV2)분별위10.7％、12.0％、9.4％;A조、B조수축압변이계수차이유통계학의의(P＜0.01),서장압변이계수차이무통계학의의(P＞0.05).A조、B조、C조25간기유생소D{25(OH)D}수평분별위(87.8±29.7)nmol/L、(34.9토18.9)nmol/L、(101.0±25.5)nmol/L,조간량량비교차이유통계학의의(P＜0.05);A조중2례뇌정맥혈전환자급B조중6례뇌정맥혈전환자혈장DD함량분별위(1067±189) μg/L、(1160±177) μg/L,차이무통계학의의(P＞0.05).결론 비운동조고혈압환자보편존재VitD함량불족혹결핍;운동조수축압변화적리산정도교보통조명현수착;량조서장압적리산정도차이무통계학의의;뇌부미혈전형성여혈장DD함량명현관련;괄도운동유리우환자혈압공제병유효감소환자뇌부정맥미혈전형성.
Objective To research the correlation between the levels of vitamin D (VitD) and D-dimer (DD) and cerebral venous thrombosis in patients with hypertension and to provide some references for health advice.Methods Hypertensive patients were divided into an exercise group and a normal group.Each group's plasma DD level were determined with automatic immune fluorimetry,and serum VitD level ELISA.The results were counted respectively.The patients' life habit was investigated through questionnaires; the patients doing more than 10 km outdoor exercise weekly were set as an exercise group(group A,n=50),others a normal group(group B,n=50).All patients were cranially examined with Doppler ultrasound to judge the formation of head vein thrombosis and the results were compared.All groups' blood pressure were regularly detected for one year to assess the correlation between the levels of VitD and DD and blood pressure in patients with cerebral venous thrombosis.50 healthy people were chosen as a control group(group C).Results The level of DD was (597±163) μtg/L in group A,(615±201) μg/L in group B,and (85±15) μg/L in group C,with statistical differences between groups A and B and group C (P＜0.05).The systolic pressure and diastolic pressure were (144±16) mmHg and (87±9) mmHg in group A,(145±27) mmHg and (89±10) mmHg in group B,and (115±6) mmHg and (71±5) mmHg in group C.The coefficient of variation (CV1) of systolic pressure was 11.4％ in group A,18.9％ in group B,and 6.7％ in group C,with a statistical difference between group A and group B (P＜0.01); the coefficient of variation (CV2) of diastolic pressure was 10.7％ in group A,12.0％ in group B,and 9.4％ in group C,with no statistical difference between group A and group B (P＞0.05).The levels of 25-hydroxyvitamin was (87.8±29.7) nmol/L in group A,(34.9±18.9) nmol/L in group B,and (101.0±25.5) nmol/L in group C,with statistical differences between the three groups (P＜0.05).The level of plasma DD was (1067±189) μtg/L in two patients with cerebral venous thrombosis in group A and (l160±177)μg/L in six patients with cerebral venous thrombosis group B,with no statistical difference (P＞0.05).Conclusions Patients with hypertension not doing exercise group is insufficient or lack of VitD.Discrete degree of systolic blood pressure is significantly narrower patients doing than not doing exercise,but with no statistical difference.Brain micro-thrombosis correlates with plasma DD.Moderate exercise was beneficial for controlling blood pressure and reducing cerebral venous micro-thrombosis.
