CAJ | 학술논문

目的探讨急性颅脑损伤程度与局部脑血流量(rCBF)、局部脑血容量(rCBV)、血液通过组织的平均通过时间(MTT)之间的相关性,为早期诊断和预后评价提供可能的依据.方法本次研究纳入急性颅脑损伤患者67例.根据格拉斯哥昏迷评分(GCS)分为轻型组、中型组和重型组.入院进行320排螺旋CT的灌注成像(CTP)检测rCBF、rCBV和MTT,分析颅脑损伤程度与rCBF、rCBV和MTT之间的关系.随访患者6个月后的预后情况,与rCBF、rCBV和MTT进行相关分析.结果重型组rCBV与rCBF明显低于轻型组,而重型组MTT明显要高于轻型组,显示出与rCBF和rCBV相反的变化趋势(P＜0.05).rCBV与格拉斯哥预后评分(GOS)呈明显的正相关(P＜0.01),MTT与GOS呈明显的负相关,而rCBF与GOS并无明显的相关性.结论 rCBF、rCBV和MTT与急性颅脑损伤严重程度和患者的预后存在相关性,在评估急性颅脑损伤严重程度及预后时有一定的参考价值.
목적 탐토급성로뇌손상정도여국부뇌혈류량(rCBF)、국부뇌혈용량(rCBV)、혈액통과조직적평균통과시간(MTT)지간적상관성,위조기진단화예후평개제공가능적의거.방법 본차연구납입급성로뇌손상환자67례.근거격랍사가혼미평분(GCS)분위경형조、중형조화중형조.입원진행320배라선CT적관주성상(CTP)검측rCBF、rCBV화MTT,분석로뇌손상정도여rCBF、rCBV화MTT지간적관계.수방환자6개월후적예후정황,여rCBF、rCBV화MTT진행상관분석.결과 중형조rCBV여rCBF명현저우경형조,이중형조MTT명현요고우경형조,현시출여rCBF화rCBV상반적변화추세(P＜0.05).rCBV여격랍사가예후평분(GOS)정명현적정상관(P＜0.01),MTT여GOS정명현적부상관,이rCBF여GOS병무명현적상관성.결론 rCBF、rCBV화MTT여급성로뇌손상엄중정도화환자적예후존재상관성,재평고급성로뇌손상엄중정도급예후시유일정적삼고개치.
Objective To investigate the relevance between the seriousness of acute brain injury and regional cerebral blood flow (rCBF),regional cerebral blood volume (rCBV) or mean transition time (MTT) ; provide a possible method for the early diagnose and prognostic evaluation.Methods This study included 67 patients of acute brain injury and they were divided into mild,moderate and severe groups based on their glasgow coma scale (GCS) scores.They were examined to detect rCBF,rCBV and MTT by computed tomography perfusion (CTP) imaging after admittcd to hospital.The prognoses of them after 6 months of follow-up were also recorded.The relations between the prognosis and rCBF,rCBV or MTT were analyzed.Results rCBV and rCBF of severe group were significantly lower than the mild group (P ＜ 0.05),and MTT of severe group was significantly higher than that of the mild group (P ＜ 0.05).The rCBV and the glasgow outcome scale (GOS) scores were significantly positively correlated (P ＜ 0.01),and MTT was significantly negatively correlated with the GOS score (P ＜ 0.01).Whereas there was no correlation between rCBF and the COS score.Conclusion rCBF,rCBV and MTT were significantly correlated with the severity as well as the prognosis of patients with acute brain injury and they might be used as potential indicators of the severity and prognosis.