中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2015年
1期
80-83
,共4页
姚鹏飞%杨鹏飞%张照龙%刘建民%黄清海
姚鵬飛%楊鵬飛%張照龍%劉建民%黃清海
요붕비%양붕비%장조룡%류건민%황청해
基底动脉%血流动力学%血管重构%血管造影术
基底動脈%血流動力學%血管重構%血管造影術
기저동맥%혈류동역학%혈관중구%혈관조영술
Basilar artery%Hemodynamic%Vascular remodeling%Angiography
目的 探讨基底动脉血流动力学改变后基底动脉形态及病理变化.方法 新西兰大白兔双侧颈总动脉结扎以代偿性增加椎基底动脉血流,分别于术前及术后1d、1周、2周经颅多普勒检测基底动脉血流速度;术后1周、2周分别行脑血管造影,并且测量基底动脉直径及迂曲程度;对基底动脉病理切片EVG、Masson染色分析.结果 颈总动脉结扎后基底动脉血流明显增快(10.99 ml/min对比36.53 ml/min,P＜0.001),术后1周、2周基底动脉直径增大(0.60 mm对比0.82 mm;0.73 mm对比1.03 mm,P＜0.001),内弹力层完整,平滑肌层增生;并且迂曲成角,57.1％基底动脉向左侧弯曲,较术前差异有统计学意义(P＜0.05).结论 基底动脉血流动力学增加是导致基底动脉迂曲成角的主要原因.
目的 探討基底動脈血流動力學改變後基底動脈形態及病理變化.方法 新西蘭大白兔雙側頸總動脈結扎以代償性增加椎基底動脈血流,分彆于術前及術後1d、1週、2週經顱多普勒檢測基底動脈血流速度;術後1週、2週分彆行腦血管造影,併且測量基底動脈直徑及迂麯程度;對基底動脈病理切片EVG、Masson染色分析.結果 頸總動脈結扎後基底動脈血流明顯增快(10.99 ml/min對比36.53 ml/min,P＜0.001),術後1週、2週基底動脈直徑增大(0.60 mm對比0.82 mm;0.73 mm對比1.03 mm,P＜0.001),內彈力層完整,平滑肌層增生;併且迂麯成角,57.1％基底動脈嚮左側彎麯,較術前差異有統計學意義(P＜0.05).結論 基底動脈血流動力學增加是導緻基底動脈迂麯成角的主要原因.
목적 탐토기저동맥혈류동역학개변후기저동맥형태급병리변화.방법 신서란대백토쌍측경총동맥결찰이대상성증가추기저동맥혈류,분별우술전급술후1d、1주、2주경로다보륵검측기저동맥혈류속도;술후1주、2주분별행뇌혈관조영,병차측량기저동맥직경급우곡정도;대기저동맥병리절편EVG、Masson염색분석.결과 경총동맥결찰후기저동맥혈류명현증쾌(10.99 ml/min대비36.53 ml/min,P＜0.001),술후1주、2주기저동맥직경증대(0.60 mm대비0.82 mm;0.73 mm대비1.03 mm,P＜0.001),내탄력층완정,평활기층증생;병차우곡성각,57.1％기저동맥향좌측만곡,교술전차이유통계학의의(P＜0.05).결론 기저동맥혈류동역학증가시도치기저동맥우곡성각적주요원인.
Objective To explore the basilar artery morphology and pathology after hemodynamic changes of basilar-artery.Methods New Zealand white rabbits were subjected to bilateral common carotid artery ligafion to produce compensatory vertebrobasilar artery flow increase.The basilar artery flow velocity was monitored by transcranial Doppler before the procedure and at 1 day,1 week and 2 weeks after the procedure.DSA was performed at 1 week and 2 weeks after the procedure respectively and the basilar artery diameter and the extent of toauosity were measured.The basilar artery tissues were harvested at 1 week and 2 weeks after the procedure and examined histologically by EVG and Masson staining.Results The basilar artery flow velocity of New Zealand white rabbit was increased significantly subjected to common carotid artery ligation (10.99 ml/min vs 36.53 ml/min,P ＜0.001).One or two weeks after surgery,the basilar artery diameter was expanded (0.60 mm vs 0.82 mm; 0.73 mm vs 1.03 mm,P ＜0.001),and the artery was curved.The internal elastic layer of artery was intact with smooth muscle cells proliferation in response to high flow and shear stress.The basilar artery was bent to the left side in 57.1％ of all rabbits and there was significant difference compaared with that of preoperafion.Condusions The hemedynamic increasing of the basilar artery after bilateral common carotid artery ligation of New Zealand white rabbits resulted in expansion and tortuosity of the basilar artery.
