CAJ | 학술논문

目的探讨伽玛刀治疗颅底软骨肉瘤的临床效果.方法回顾分析2007年10月至2013年12月6例软骨肉瘤患者资料,男5例,女1例;年龄28 ～ 65岁,平均45.6岁.所有患者均经手术病理证实为软骨肉瘤.其中间叶型软骨肉瘤1例,标准型软骨肉瘤5例.肿瘤体积4.7 ～62.4 cm3,平均16.8 cm3.周边剂量10～ 14 Gy(平均13.3 Gy,中位13.5 Gy),中心剂量26～31 Gy(平均29.1 Gy,中位28.6 Gy),伽玛刀治疗后随访时间6～51个月(平均29.3个月,中位27.0个月).结果 1例间叶型软骨肉瘤患者术后15个月死亡,1例术后27.0个月复发,再次行伽玛刀治疗,随访至今肿瘤控制良好.4例肿瘤控制良好,且无放射相关并发症出现.结论伽玛刀作为颅底软骨肉瘤的术后辅助治疗安全且有效.
목적 탐토가마도치료로저연골육류적림상효과.방법 회고분석2007년10월지2013년12월6례연골육류환자자료,남5례,녀1례;년령28 ～ 65세,평균45.6세.소유환자균경수술병리증실위연골육류.기중간협형연골육류1례,표준형연골육류5례.종류체적4.7 ～62.4 cm3,평균16.8 cm3.주변제량10～ 14 Gy(평균13.3 Gy,중위13.5 Gy),중심제량26～31 Gy(평균29.1 Gy,중위28.6 Gy),가마도치료후수방시간6～51개월(평균29.3개월,중위27.0개월).결과 1례간협형연골육류환자술후15개월사망,1례술후27.0개월복발,재차행가마도치료,수방지금종류공제량호.4례종류공제량호,차무방사상관병발증출현.결론 가마도작위로저연골육류적술후보조치료안전차유효.
Objective To assess outcomes after gamma knife radiosurgery for chondrosarcomas of the skull base.Methods Six patients (one female and five male) with skull base chondrosarcomas were reviewed who underwent gamma knife treatment between 2007 and 2013.The mean patient age was 45.6 years (range 28-65 years).All patients were diagnosed as chondrosarcoma by histological confirmation.All patients had no radiation therapy experience.The mean tumor volume was 16.8 cm(range 4.7-62.4 cm) and mean/median margin dose was 13.3/13.5 Gy (range 10-14 Gy),and the mean/median tumor maximum dose was 29.1/28.6 Gy(range 26-31 Gy).The mean/median followed up time was 29.3/27.0 months (range 6-51 months).Results One paitent who was diagnosisd as mesenchymal chondrosareoma dead at 15 months after gamma knife treatment because of tumor progression at 27 months,one patient underwent repeat gamma knife treatment,and the tumor progression free until now.Other 4 patient keep tumor progression free.No symptomatic adverse radiation effects occurred.Conclusion Stereotactic radiosurgery provide a benefit to patients as a adjuvant therapy for skull base chondrosarcoma.