CAJ | 학술논문

目的探讨皮质下直接电刺激(DES)在功能区弥漫性低级别胶质瘤(DLGG)切除手术中的意义.方法回顾性分析自2010年1月至2014年5月进行手术治疗并于术中应用皮质下DES的57例大脑功能区DLGG的临床资料.结果术中皮质下DES均能在肿瘤周边发现锥体束、丘脑上辐射或语言相关白质纤维,从而达到按功能边界切除肿瘤的目的.全切除20例(35％),次全切26例(46％),部分切除11例(19％).46例(81％)出现早期神经功能障碍,其中轻度15例(26％),中度21例(37％),重度10例(18％);4例出现晚期神经功能障碍,其中轻度3例(5％),中度1例(2％),重度0例.术前有癫痫发作的55例中,48例(87％)术后无癫痫发作;其余7例发作频率较术前减少＞50％.结论唤醒开颅下应用皮质下DES可在不降低远期生活质量的前提下最大安全切除DLGG,但早期神经功能障碍发生率高,需康复治疗.
목적 탐토피질하직접전자격(DES)재공능구미만성저급별효질류(DLGG)절제수술중적의의.방법 회고성분석자2010년1월지2014년5월진행수술치료병우술중응용피질하DES적57례대뇌공능구DLGG적림상자료.결과 술중피질하DES균능재종류주변발현추체속、구뇌상복사혹어언상관백질섬유,종이체도안공능변계절제종류적목적.전절제20례(35％),차전절26례(46％),부분절제11례(19％).46례(81％)출현조기신경공능장애,기중경도15례(26％),중도21례(37％),중도10례(18％);4례출현만기신경공능장애,기중경도3례(5％),중도1례(2％),중도0례.술전유전간발작적55례중,48례(87％)술후무전간발작;기여7례발작빈솔교술전감소＞50％.결론 환성개로하응용피질하DES가재불강저원기생활질량적전제하최대안전절제DLGG,단조기신경공능장애발생솔고,수강복치료.
Objective To report our experience of intraoperative subcortical napping by direct electrical stimulation in surgery of diffuse low-grade gliomas in supratentorial eloquent areas.Methods We conducted a retrospective analysis of clinical data of 57 patients with diffuse low-grade gliomas who were underwent awake craniotomy with the direct electrical stinulation for subcortical mapping of the eloquent fibers.The maximal resection of the tumors and minimal damage of the eloquent fibers were the surgical goal of all patients.Results The operation was stopped by individual functional boundaries as intra-operatively identification of the cortico-spinal pathways,or superior thalamic radiation,or language-related pathways in all patients.Post-operative MRI showed that 20 patients (35％) were achieved total resection,26(46％) subtotal and 11 partial(19％).11 patients (19％) had no postoperative deficits,while 46 patients (81％) had early post-operative neurologic deficits,including 15 patients with mild neurologic deficits,21 with moderate,and 10 with severe.Four patients experienced late post-operative neurologic deficits,including 3 patients with mild deficits,1 moderate.No one experienced severe late post -operative sequelae.Among 55 patients with pre-operative epilepsy,48 patients (87％) were seizure-free with taking anti-epilepsy drugs during seven days to three months after surgery,The frequency of post-surgical seizure attack in the remaining seven patients was decreased by 50％ compared with that of pre-operation.Conclusion Intraoperative subcortical mapping of the functional fibers by direct electrical stimulation under awake craniotomy allowed neurosurgeons to remove diffuse low-grade gliomas in supratentorial eloquent areas according to individual functional boundaries without increasing the late post-operative neurological deficits.However,frequent early postoperative neurological deficits often necessitated rehabilitation therapy.