中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2014年
12期
1235-1238
,共4页
吴刚%胡枢坤%常川%陈炜%沙龙贵%高翔%郑康
吳剛%鬍樞坤%常川%陳煒%沙龍貴%高翔%鄭康
오강%호추곤%상천%진위%사룡귀%고상%정강
脑出血%铁%去铁敏%磁共振成像
腦齣血%鐵%去鐵敏%磁共振成像
뇌출혈%철%거철민%자공진성상
Intracerebralhemorrhage%Iron%Deferoxamine%Magnetic resonance imaging
目的 评价用去铁敏治疗临床自发性脑出血患者的安全性和疗效.方法 临床自发性脑出血病例共29例进入观察序列,其中去铁敏治疗组19例,对照组10例,发病后静脉注射去铁敏针剂,发病第1、7和14天行脑部MRI T2WI和T2 *WI扫描,Image J软件进行图像分析,发病第7、14和90天行神经功能评估.结果 患者使用去铁敏后,未出现药物相关不良反应.患者脑出血后第1、7和14天治疗组脑组织相对水肿程度(1.08±0.57、1.37±0.68、1.52 ±0.69)比对照组(1.89±0.77、2.03±0.71、2.07 ±0.87)明显减轻(P＜0.05);脑出血后第7和14天治疗组相对血肿体积(0.96±0.21、0.89 ±0.23)比对照组(1.16 ±0.23、1.24±0.49)明显缩小(P＜0.05);脑出血后第7和14天治疗组患者神经功能(11.7±4.1、7.4±2.6)比对照组(15.1±4.9、11.8±5.6)明显好转(P＜0.05).结论 去铁敏对临床自发性脑出血患者的治疗有明显的效果.
目的 評價用去鐵敏治療臨床自髮性腦齣血患者的安全性和療效.方法 臨床自髮性腦齣血病例共29例進入觀察序列,其中去鐵敏治療組19例,對照組10例,髮病後靜脈註射去鐵敏針劑,髮病第1、7和14天行腦部MRI T2WI和T2 *WI掃描,Image J軟件進行圖像分析,髮病第7、14和90天行神經功能評估.結果 患者使用去鐵敏後,未齣現藥物相關不良反應.患者腦齣血後第1、7和14天治療組腦組織相對水腫程度(1.08±0.57、1.37±0.68、1.52 ±0.69)比對照組(1.89±0.77、2.03±0.71、2.07 ±0.87)明顯減輕(P＜0.05);腦齣血後第7和14天治療組相對血腫體積(0.96±0.21、0.89 ±0.23)比對照組(1.16 ±0.23、1.24±0.49)明顯縮小(P＜0.05);腦齣血後第7和14天治療組患者神經功能(11.7±4.1、7.4±2.6)比對照組(15.1±4.9、11.8±5.6)明顯好轉(P＜0.05).結論 去鐵敏對臨床自髮性腦齣血患者的治療有明顯的效果.
목적 평개용거철민치료림상자발성뇌출혈환자적안전성화료효.방법 림상자발성뇌출혈병례공29례진입관찰서렬,기중거철민치료조19례,대조조10례,발병후정맥주사거철민침제,발병제1、7화14천행뇌부MRI T2WI화T2 *WI소묘,Image J연건진행도상분석,발병제7、14화90천행신경공능평고.결과 환자사용거철민후,미출현약물상관불량반응.환자뇌출혈후제1、7화14천치료조뇌조직상대수종정도(1.08±0.57、1.37±0.68、1.52 ±0.69)비대조조(1.89±0.77、2.03±0.71、2.07 ±0.87)명현감경(P＜0.05);뇌출혈후제7화14천치료조상대혈종체적(0.96±0.21、0.89 ±0.23)비대조조(1.16 ±0.23、1.24±0.49)명현축소(P＜0.05);뇌출혈후제7화14천치료조환자신경공능(11.7±4.1、7.4±2.6)비대조조(15.1±4.9、11.8±5.6)명현호전(P＜0.05).결론 거철민대림상자발성뇌출혈환자적치료유명현적효과.
Objective To explore the therapeutic results of deferoxamine in the treatment of spontaneous intracerebral hemorrhage (SICH).Methods A total of 29 spontaneous intracerebral hemorrhage patients were collected from 4 clinical centers in Shanghai and Ningbo City.Nineteen cases received deferoxamine treatment as the treatment group,and l0 cases received routine therapy as the control group.Deferoxamine was given after the onset of stroke for a consecutive of 3 days.All cases had brain MRI T2WI and T2 * WI scanning at the 1st,7th and 14th days after the onset.The image features were recorded and image analysis was performed by the software of Image J.The neurological function was evaluated at the 7th,14th and 90th days after the stroke.Results Patients in the treatment group didn't show any drug related side effect.The cerebral edema in the treatment group patients with at the 1st、7th and 14th days (1.08 ±0.57、1.37 ±0.68、1.52 ±0.69) were lighter than those in the control group(1.89 ±0.77、2.03 ± 0.71、2.07 ±0.87) (P ＜0.05).The hematoma volumes of the treatment group patients at the 7th and 14th days (0.96 ±0.21、0.89 ±0.23) were smaller than those in the control group (1.16 ±0.23、1.24 ±0.49) (P ＜0.05).The neurological function in the treatment group patients at the 7th and 14th days after SICH (11.7 ± 4.1、7.4 ± 2.6) was better than that in the control group (15.1 ± 4.9、11.8 ± 5.6) (P ＜ 0.05).Conclusion Deferoxamine had obvious therapeutic effect on the clinical treatment of patients with SICH.
