中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
1期
23-27
,共5页
何泱%许蕾%钱泓洁%张杉杉%顾雪明%顾俊义%施建元%沈亚萍%汤正义
何泱%許蕾%錢泓潔%張杉杉%顧雪明%顧俊義%施建元%瀋亞萍%湯正義
하앙%허뢰%전홍길%장삼삼%고설명%고준의%시건원%침아평%탕정의
糖尿病足溃疡%雌二醇%睾酮%游离睾酮
糖尿病足潰瘍%雌二醇%睪酮%遊離睪酮
당뇨병족궤양%자이순%고동%유리고동
Diabetic foot ulcer%Estradiol%Testosterone%Free testosterone
目的 分析男性糖尿病足溃疡(DFU)患者的性激素水平与病情严重性的相关性,探讨男性DFU患者预后的影响因素.方法 收集204例男性DFU患者和63例高危DFU患者的基本资料,测定这些患者入院时血中卵泡刺激素、黄体生成素、催乳素、雌二醇、孕酮、睾酮、游离睾酮(FT)、性激素结合球蛋白水平;随访观察DFU患者6个月溃疡愈合、复发、心脑血管事件及死亡情况.结果 随着Wagner级别增加,男性患者体内雌二醇水平上升(P趋势 =0.001 2),睾酮、FT水平下降(P趋势值分别为0.005、0.0027);随着DFU感染加重,男性患者体内催乳素呈升高趋势(P趋势=0.021),FT水平下降(P趋势=0.007);患者体内雌二醇水平增高是DFU患者心脑血管事件发生(OR=1.11,P＜0.05)和死亡(OR=1.01,P＜0.05)的危险因素.结论 男性DFU患者垂体-性腺轴功能发生异常改变,多项指标似可提示病情严重性并帮助判断预后.
目的 分析男性糖尿病足潰瘍(DFU)患者的性激素水平與病情嚴重性的相關性,探討男性DFU患者預後的影響因素.方法 收集204例男性DFU患者和63例高危DFU患者的基本資料,測定這些患者入院時血中卵泡刺激素、黃體生成素、催乳素、雌二醇、孕酮、睪酮、遊離睪酮(FT)、性激素結閤毬蛋白水平;隨訪觀察DFU患者6箇月潰瘍愈閤、複髮、心腦血管事件及死亡情況.結果 隨著Wagner級彆增加,男性患者體內雌二醇水平上升(P趨勢 =0.001 2),睪酮、FT水平下降(P趨勢值分彆為0.005、0.0027);隨著DFU感染加重,男性患者體內催乳素呈升高趨勢(P趨勢=0.021),FT水平下降(P趨勢=0.007);患者體內雌二醇水平增高是DFU患者心腦血管事件髮生(OR=1.11,P＜0.05)和死亡(OR=1.01,P＜0.05)的危險因素.結論 男性DFU患者垂體-性腺軸功能髮生異常改變,多項指標似可提示病情嚴重性併幫助判斷預後.
목적 분석남성당뇨병족궤양(DFU)환자적성격소수평여병정엄중성적상관성,탐토남성DFU환자예후적영향인소.방법 수집204례남성DFU환자화63례고위DFU환자적기본자료,측정저사환자입원시혈중란포자격소、황체생성소、최유소、자이순、잉동、고동、유리고동(FT)、성격소결합구단백수평;수방관찰DFU환자6개월궤양유합、복발、심뇌혈관사건급사망정황.결과 수착Wagner급별증가,남성환자체내자이순수평상승(P추세 =0.001 2),고동、FT수평하강(P추세치분별위0.005、0.0027);수착DFU감염가중,남성환자체내최유소정승고추세(P추세=0.021),FT수평하강(P추세=0.007);환자체내자이순수평증고시DFU환자심뇌혈관사건발생(OR=1.11,P＜0.05)화사망(OR=1.01,P＜0.05)적위험인소.결론 남성DFU환자수체-성선축공능발생이상개변,다항지표사가제시병정엄중성병방조판단예후.
Objective To investigate the association of sex hormones with the severity of diabetic foot ulcer (DFU),and to analyze the influential factors of proguosis in male patients with DFU.Methods The clinical data of 204 hospitalized male patients with DFU and 63 male patients with high risk of DFU were collected.Serum concentrations of sex hormones from these patients,including FSH,LH,prolactin,estradiol,progesterone,testosterone,free testosterone (FT),and sex hormone binding globulin were tested at admission.Patients were followed for 6 months to observe the rate of wound healing and recu rrence,the occurrences of cardiovascular and cerebrovascular events,as well as the all-cause death.Results In male patients with DFU,the serum concentration of estradiol increased gradually with the increase of Wagner grades (Ptrend =0.001 2),while testosterone and FT decreased(Ptrend =0.005 and P =0.002 7).The serum concentration of prolactin increased with the severity of infection(Ptrend =0.021),while FT(Ptrend =0.007) decreased.High level of estradiol was one of the risk factors associated with the occurrences of cardiovascular and cerebrovascular events(OR =1.11,P＜0.05) and death (OR =1.01,P＜0.05) in male patients with DFU.Conclusions The hormones secreted from pituitary-gonadal axis are changed in male patients with DFU.Abnormality of these hormones might suggest the severity and prognosis of DFU.
